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Role of Ketamine, Levetiracetam and LCarnitine in Aminophylline Induced Seizure in Wister Rat Model

Background: Aminophylline-induced seizure is commonly fatal and no specific, pharmacologically antagonistic drug is known. But recently, free radicals have been implicated in Aminophylline induced toxicities.
Aim: The present study was conducted whether simply anticonvulsant drug or anticonvulsants that mediated by reduction of oxidative stress or just antioxidant can alleviate the aminophyllineinduced seizure threshold as well as mortality.
Method: Male Wister rats (n = 40) were randomly selected and divided into four groups. One group was injected Aminophylline 300mg/kg intrperitoneally (control group), second group was administered aminophylline 300 mg/kg intraperitoneally 5min after giving Ketamine (100mg/kg i.p.), in third group l-carnitine, was administered intraperitoneally with a rapid infusion (0.05 g/kg) diluted in 250 ml of saline solution before introducing Aminophylline 300mg/kg intraperitoneally and third group Levetiracetam (200 mg/kg, i.p.) was injected intraperitoneally 60 min before inducing Aminophylline-induced seizures (300 mg/kg, i.p.).
Result: Pretreatment with Ketamine, showed no antagonizing effects on seizurogenic effect of aminophylline (300 mg/kg) and 24 hr postseizure mortality. But when L-carnitine and Levetiracetam were given isolated therapy before the aminophylline they reduce 10% and 40% aminophylline induced seizure threshold as well as mortality respectively. Malondialdehyde and Protein carbonyls product formation were significantly suppressed and Superoxide dismutase activity was improved in different areas of brain by L-carnitine and Levetiracetam administration (p < 0.001) than control group whereas Ketamine neither decreased oxidative stress nor seizure threshold as well as mortality significantly. Conclusion: Anticonvulsive drug that are acted by correction of disturbed redox balance is better to treat Aminophylline-induced seizure than Anticonvulsants are acted by other ways.

Author(s): Uttam Kumar Roy, Subinay Datta, Mrinal Pal, Shanwer Harlalka, Amit Kumar Pradhan, Sudipta Sil, Amrita Ganguly2 and Shubhadeep Basu

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