Outcomes of in vitro fertilization in infertile patients with early-stage endometrial cancer or atypical endometrial hyperplasia: an analysis of 31 cases

Aim: To assess the effectiveness of intracytoplasmic sperm injection (ICSI) or in vitro fertilization (IVF) and embryo transfer (IVF-ET) in infertile patients with early-stage endometrial cancer (EC) or atypical endometrial hyperplasia (AEH).

Methods: Patients with well-differentiated, early-stage EC or AEH who achieved complete reversion of the endometrium after conservative treatment and who underwent IVF-ET between January 2012 and December 2015 were collected. Fertilization rate, implantation rate, pregnancy rate and AEH/EC recurrence rate were measured.

Results: A total of 31 patients were included, of whom 25 (80.65%) had AEH and 6 (19.35%) had well-differentiated early-stage EC. Mean duration of conservative treatment was 8.25±4.08 months, while mean age at entering the IVF cycle was 34.9±3.8 years. The average number of embryos transferred was 1.7 ± 0.8. The IVF and ICSI fertilization rates were 77.6% and 68.2%, respectively. The implantation and pregnancy rates were 29.6% (16/54) and 41.9% (13/31), respectively. There were 13 cases of intrauterine pregnancy with a clinical pregnancy rate of 41.9%. Recurrence of endometrial lesion occurred in 2 (6.45%) patients.

Conclusions: Assisted reproductive technology is a good option in well-selected patients with early-stage EC or AEH who show complete reversion of the endometrial lesion after conservative therapy.

Author(s): Yuanzheng Zhou, Shengyuan Ran, Ling Weng, Chengyan Deng, Fangfang He, Zhengyi Sun, Hanbi Wang, Jingran Zhen1, Qi Yu

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