In this present study, the root extracts of Withania somnifera were subjected to a comparative evaluation of the membrane stabilization and thrombolytic activity on human blood sample. The thrombolytic and membrane stabilizing activities were assessed by using human erythrocyte and the results were compared with standard streptokinase (SK) and standard anti-inflammatory drug, acetyl salicylic acid (ASA), respectively. The Methanol extract showed the highest thrombolytic activity (68.14%). On the other hand hypotonic solution induced haemolysis, at a concentration of 1.0 mg/ mL, the methanol extract inhibited 71.90% haemolysis of RBCs as compared to 73.56% produced by acetyl salicylic acid (0.10 mg/mL). And in case of heat induced condition different organic soluble materials of Withania somnifera demonstrated 54.03%, 53.13% and 38.54% inhibition of hemolysis of RBCs, respectively whereas ASA inhibited 48.10%.
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