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In-vitro and In-vivo Screening Methods for Antithrombotic Agents

Thrombolytic therapy and mechanical interventions are frequently used in the treatment of thrombotic diseases. The basic problems with current thrombolytic therapy include slow and incomplete thrombolysis and frequent bleeding complications. Therefore, there is a need of continuity to develop & screen out the various natural agents that possess antithrombotic activity by using different screening methods. The experimental thrombotic methods can be classified into two groups-fibrin rich red thrombi are produced in veins by stasis or procoagulant. The platelets rich white mural thrombi are produced in artery by vessel wall injury or stenosis. Thrombosis models are usually performed in healthy animals not included atherosclerosis or throbophilias. But no one method yet to develop that completely resembles to pathophysiology of thrombosis of human beings. So it’s better to evaluate any new compound in more than one model for clear clinical relevance, the pharmacological effectiveness. Presently the research in new drug discovery utilizes combinatorial chemistry, computer aided drug design, quantitative structural activity relationship, ADME-T and bioinformatics. In spite of several developments, screening and evaluation methods remain a challenge for pharmacology. This review contains numerous simplest and most widely accepted techniques of drug evaluation in precise and concise manner.

Author(s): Kamal Kishore

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