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Abstract

Impress of EBV RNA (EBERs) and P16 on Grades of Prostate Carcinoma

Prostate carcinoma (PCa) is second most common cancer in men in the world and first most common cancer in American and European men. Epstein Barr virus (EBV) is directly infects B cells and lead to transform of these cells into apoptotic-resistant B cells, EBV is an etiological agent in carcinomas of the breast, lung, colon and prostate, in addition to nasopharyngeal carcinoma (NPC) and gastric carcinoma (GC). PCa varies in their proliferative rate, mostly grow slowly and many of patient die with small undiagnosed PCa and only small proportion of this cancer shows rapid proliferation rate and spread to outside of prostate with preference to the bones and lymph nodes. The aim of this study is detection of EB encoded RNAs (EBERs) and tumor suppressor protein (P16) in Prostate carcinoma as well as their association with its grades. To achieve this purpose In situ hybridization (CISH) was used to detect the presence of EBERs and Immunohistochemistry (IHC) to evaluate the over expression of mutated p16 tumor suppressor gene in tissue after collected thirty 30 formalin-fixed Paraffin embedded tissue blocks were obtained from prostate carcinoma biopsies Transurethral Resection of Prostate (TURP) during the period from May 2016 to December 2016. The grade of cancer evaluated as following: {Grade I=≤6, Grade II=(3+4)=7, Grade III=(4+3)=7, Grade IV=(4+4)=8, Grade V=9+10}. From this study we can conclude the presence of EBERs and P16markers in all PCa grades but highly percentage in grade III because the high percentage of samples in this study from this grades, and presence of EBV increase the proliferation, may be inhibit tumor suppressor protein and killing immune cells.


Author(s): Layla Abd AL-Kareem Waheed, Basim Shab Ahmed and Dawood Salman

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