Objectives: The Liver is the largest organ in the body carrying out most of the biochemical synthesis and secretary functions. Living in a world of inadequately controlled environment, pollution and expanding therapy with potent drugs, it is continuously exposed to variety of xenobiotics and therapeutic agents resulting in its structural or functional damage. In an attempt to establish its pharmacological potential, we studied the Hepatoprotective activity of alcohol extract of Aegle marmelos obtained via extraction of air-dried leaves.
Methods: The rats were administered the ethanol extract (dose range of 100 mg/kg) orally for 15 days. The animals were randomly divided in to four groups, each containing three animals. They were subjected to the intraperitoneal injection of bacterial suspension at a dose of 5 X 106 CFU/0.1 mL once in every three days. Then the animals were treated with the alcoholic extract of Aegle marmelos daily for 15 days in physiological saline at concentration of 100mg/kg of body weight. The Silymerin (25mg/kg) was used as the standard control.
Results: At a dose of 100 mg/kg, the extract produced no sign of toxicity in rats. The extract exhibited significant (p < 0.05) dosedependent Hepatoprotective activity for the Staphylococcus aureus induced model. In alcoholic extract of treated groups there was statistical significant decrease in the levels of serum bilirubin, serum glutamate oxaloacetate transminase (SGOT), serum glutamate pyruvate transminase (SGPT) and serum alkaline phosphatase (SALP) as compared to the hepatotoxic group. In the liver by a significant reduction in the activity levels of superoxide dismutase, catalase, glutathione peroxidase, gluthaione-s-transferase, glutathione reductase and also reduced glutathione content were observed in the liver of S. aureus intoxicated rats over the control.
Conclusion: The alcoholic extracts of the leaves of Aegle marmelos possess Hepatoprotective activity, Anti stress, anti oxidant properties that may be due to cytoprotective mechanism.
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