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Abstract

Evaluation of In Vitro Anti-Oxidant, Anti- Nociceptive and Anti-Inflammatory properties of Desmodium gangeticum (L.) in Experimental Animal Models

The study was undertaken to evaluate the antioxidant activity of ethanolic extract of Desmodium gangeticum and compared with ascorbic acid (Standard) and the analgesic and anti-inflammatory activities in animal models. The extract has an anti-inflammatory effect demonstrated by its inhibitory effects on Carrageenan induced paw edema. Desmodium gangeticum leaves were studied indifferent models of inflammation in rats after oral administration at doses of 50, 100 and 200mg/kg. Desmodium gangeticum leaves significantly inhibited carrageenin, paw edema. It also produced significant increase in the hot plate reaction time in mice indicating analgesic effect. Anti-oxidant activity of ethanolic extracts of Desmodium gangeticum leaves was studied for its free radical scavenging property in different in vitro methods as 1, 1 diphenyl-2- picrylhydrazyl, nitric oxide, reducing power assay and hydrogen peroxide radical method. Different concentrations of ethanolic extract of DGE were prepared and evaluated by standard methods. The IC50 values of ethanolic extract of DGE were compared with ascorbic acid (Standard) and it was noted that, the extract showed significant concentration dependent free radical scavenging property in all the methods. However this study therefore, supports its use in indigenous system of medicine both as analgesic and anti-inflammatory agent and calls for further investigations to elucidate its mechanism of action.


Author(s): Manoj Kumar Sagar, Kumud Upadhyaya

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