Background: The aim of this study was to evaluate the Invivo antiinflammatory activity of petroleum ether extract of aerial parts of Leucaslavandulaefolia
Methods:The anti-inflammatory activity was evaluated by Carrageenan induced rat paw edema to determine the activity on acute inflammation and Cotton pellet- induced granuloma to determine activity on chronic inflammation. The petroleum ether extract was administered orally at a dose of 100, 200, 400 mg/kg body weight to experimental rat. The anti-inflammatory activity was compared with standard Indomethacin.
Results:Results suggested thatpetroleum ether extract of Leucaslavandulaefolia. aerial parts possess potent anti-inflammatory activity in both the models and the activity was dose dependent. In acute inflammatory model, the effect may be due to inhibition of the release of serotonin and histamine thereby preventing inflammation and also preventing the increased synthesis of prostaglandins in the surroundings of the damaged tissues.In chronic inflammatory model, the effect may be due to inhibition of cellular migration to injured site and accumulation of collagen and mucopolysaccharide. Preliminary phytochemical screening showed presence of triterpenoids and steroids in petroleum ether extract of Leucaslavandulaefolia. aerial parts.
Conclusion:The result of present study confirms marked antiinflammatory activity of Leucaslavandulaefolia. The activity may attributed to steroids or triterpenoids in petroleum ether extract of L.lavandulaefolia.
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