Evaluation and Optimization of Antifungal Activity of Active Components of Extracts of Eucalyptus sp, on the In vitro Growth of Candida tropicalis

Infectious diseases continue to be an important public health problem. Among them, candidiasis an opportunist fungal infection especially in patients living with HIV / AIDS is on the increase. Our research team tested different plant extracts (butanolic, hexane, ethyl acetate, chloroform) of crude extract hydro-ethanolic obtained from Eucalyptus sp on the in vitro growth of Candida tropicalis. Among the 10 extracts tested, X1.2 has the highest inhibitory activity (MFC = 125 μg/mL; IC50 = 09.91 μg/mL). The method of preparation of the extract (X1.2) by partitioning of hydro-ethanolic extract in different solvent mixtures is the best way to obtain the best active principle concentration.

Author(s): Agre Don Josette, Yaye Yapi Guillaume, Ackah Jacques Auguste Alfred Bognan, Kra Adou Koffi Mathieu, Loukou Yao Guillaume and Djaman Allico Joseph

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