Plumbago zeylanica L. (Plumbaginaceae) (PZ) commonly called as Doctorbush is a semi climbing sub shrub used to effective against anaemia, rheumatic pain, dysmenorrhoea, leprosy, ulcers and elimination of intestinal parasites. In Ayurvedic system of medicine, the roots of the plant and its constituents are credited with potential therapeutic properties including cardiotonic, neuroprotective and CNS stimulating properties. The aim of this review is to provide comprehensive information on the traditional uses, phytochemistry, pharmacological actions and toxicity study of Plumbago zeylanica L to explore their therapeutic potential and future research opportunities. All the relevant information of PZ was collected through MEDLINE/PUBMED. The evidence presented in this review has showed that PZ has great potential to be integrated into conventional medical practice for the treatment of various metabolic diseases, hepatotoxic, diabetes, inflammation, cancer and other disease complications. Future research on PZ would provide much knowledge about pharmacological uses and socio-economic impact.
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