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Abstract

Development and Validation of Reversed- Phase High Performance Liquid Chromatographic Method for Estimation of Dexketoprofen Trometamol in Bulk and Tablet Dosage Form

The Literature survey indicates several methods for the determination of Dexketoprofen trometamol. So an attempt was made to develop and validate a simple, precise, accurate, and economical RP-HPLC method as per ICH guidelines for the estimation of Dexketoprofen trometamol in bulk and pharmaceutical dosage forms. A simple reverse phase HPLC method was developed for the determination of Dexketoprofen trometamol present in pharmaceutical dosage forms. C18 (4.6ID x 250mm) in an gradient mode with mobile phase Acetonitrile: Methanol (25:75) was used. The flow rate was 0.9ml/ min and effluent was monitored at 262nm. The retention time was 2.9min for Dexketoprofen trometamol. The linearity ranges were found to be 30-70μg/ml


Author(s): Kadam Archana & Patil Vikas

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