Ulcers can also be caused and worsened by drugs such as aspirin, ibuprofen and other NSAIDs. Irrational usage of NSAIDs leads to the ulceration of the stomach and sometimes found to cause perforations due to the lack of certain prostaglandin synthesis which are essential for the production of gastric mucosa. Purpose of present study was to evaluate the acute damage caused by different dosages of three NSAIDs; diclofenac sodium, mefanamic acid and piroxicam in rats to provide information for understanding the mechanism underlying acute NSAIDs- induced gastric damage. Healthy wister rats weighing 200- 250 grams were used for gastric tolerability test. Gastric tolerability of NSAIDs was determined by the pylorus ligation model and their anti-inflammatory activity was determined by carragennan induced acute paw oedema model. All of the NSAID groups showed significantly higher gross ulcer index values than the control group. The gross ulcer index increased with alone and combination of the NSAIDs in rats. Mefanamic acid treatment group and its diclofenac sodium combination showed less ulcer index when compared to other treatments. That is, the gross ulcer index in combination of Diclofenac sodium and Piroxicam was significantly higher than that of control and individual treatments. All the groups of NSAIDs showed good anti-inflammatory action. Combination of piroxicam and diclofenac sodium showed high anti-inflammatory activity compared to individual treatments. From the above results we can conclude that the combination of diclofenac sodium and piroxicam showed additive anti-inflammatory activity. Combination of diclofenac sodium and mefanamic acid was found to be well tolerated with gastric mucosa.
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