Diana Passaro Research Associate, Department of Human normal and malignant hematopoietic stem cells and their microenvironment, The Francis Crick Institute, London, UK.
Diana Passaro is a working as a Research Associate from The Francis Crick Institute. He is extending his valuable service as a Research Associate and has been a recipient of many award and grants. His research experience includes various programs, contributions and participation in different countries for diverse fields of study. His research interests as a research associate reflect in his wide range of publications in various national and international journals.
The bone marrow is the organ where adult hematopoiesis takes place producing differentiated hematopoietic lineages from multipotent progenitors/stem cells. In order to maintain the homeostasis of normal hematopoiesis a tight regulation is operated by intrinsic and extrinsic factors. Deregulation of this process led to oncogenic transformation and generation of leukemia. It has become clear that the biological and clinical behavior of hematological malignancies is not only determined by the properties of the leukemic cells themselves but it is also highly affected by the interaction with the non-malignant bone marrow microenvironment. Indeed the remodeling of the niche has been highlighted as an important step in the development of leukemia as well as during the relapse process involved in controlling the maintenance and activity of leukemia initiating cells. Thus my research work aims to decipher the differences between normal and malignant niches to provide new keys to develop non-cell-autonomous therapies for hematological malignancies.