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Polymer Congress 2018
Polymer Sciences
ISSN: 2471-9935
Page 80
June 04-05, 2018
London, UK
4
th
Edition of International Conference on
Polymer Science and
Technology
Polym Sci 2018, Volume 4
DOI: 10.4172/2471-9935-C2-012
D
endrimers are monodisperse nanosized polymeric
moleculescomposedofalargenumberofperfectlybranched
monomers. The versatile chemical composition of dendrimers
strongly offers a variety of applications in different areas such
as for instance: chemistry, catalysis, and medicine. Currently,
the potential of using dendrimers as nano-carriers for drug
delivery is revolutionizing medicine by improving the efficiency
and reducing the toxicity of various treatments. Dendrimers
can form either covalent or non-covalent (encapsulation)
bonds with bioactive molecules. In the case of covalent bond,
drug can be directly attached to dendrimer or via a linker –
cleavable or not - and the resulting drug-loaded dendrimer can
act as a nano-vehicle for drug transport and controlled release.
We will present the synthesis and characterization of original
functionalized phosphorus dendrimers (generations G1 to G3)
containing various functional groups on their peripheries such
as arene-copper (II) and ethacrynic acid moieties. Also, we will
report the studies of the very interesting cytotoxicity activities
against different solid and liquid cancer cell lines of these new
dendrimers.
n.elbrahmi@ueuromed.orgNew drug-loaded phosphorus dendrimers: Synthesis,
characterization and biological evaluation
Nabil El Brahmi
Euromed University of Fes, Morocco