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Volume 05
Journal of Clinical Nutrition & Dietetics
ISSN: 2472-1921
JOINT EVENT
June 17-18, 2019 London, UK
Nutrition World 2019
Euro Obesity 2019
June 17-18, 2019
&
26
th
World Nutrition Congress
15
th
Euro Obesity and Endocrinology Congress
Association of fasting insulin with plasma, RBC micronutrients copper and zinc in newly diagnosed type
2 diabetic patients
Humaira Binte Asad, Md Al Kamal Abdul Wahab, Shamim Ara, Khademul Azad, Neaz Ahmed
and
Forhadul Haque Molla
National Institute of ENT, Bangladesh
Statement of the Problem:
Copper and Zinc are extremely important trace elements involved in a number of
metabolic processes. Imbalance of trace elements may be the consequence of certain disorders (Khan 1994). Zn plays
a major role in the synthesis, storage and secretion of insulin as well as conformational integrity of insulin in the
hexameric form. The decreased Zn affects the ability of the islet cell to produce and secrete insulin thus compound
the problem, particularly in Type 2 diabetes. Cu is an integral part of numerous enzymes like cytochrome c- oxidase,
superoxide dismutase involved in metabolic processes.
Methodology & Theoretical Orientation:
The aim of this study was to find out the association between fasting
plasma insulin and plasma, Cu-RBC and Zn-RBC among both the control healthy, newly diagnosed type 2 DM. A
case control study was carried out in the Department of Biochemistry jointly with the Department of Endocrine
Medicine of Bangabandhu SheikhMujibMedical University. A total of 64 non-smokers, non-alcoholic, normotensive
subjects free from renal and hepatic diseases were included in this study. Among them thirty three were newly
diagnosed by type - 2 DM. Thirty one were age and sex matched healthy control.
Findings:
Mean±SD of fasting insulin was 13.13±7.87 µU/mL and 16.53±13.78 µU/mL in healthy controls and
newly diagnosed type 2 DM. The median value of RBC Zn of both groups was 6984.00 ppb (ranging 5693.50-7796.00
ppb) and 5155.50 ppb (ranging 2820- 6153 ppb) respectively (p<0.001). Significant negative correlation was found
between plasma Insulin and RBC Zn (p< 0.0001, r = -0.7881) in newly diagnosed type 2 DM. All the median values
of trace elements significantly differed between groups.
Conclusion & Significance:
Micronutrients derangement could be related to type-2 diabetes mellitus development
as well as its complications.
Biography
Humaira BinteAsad is currently serving as anAssistant Professor in Biochemistry at Laboratory Services Department at National Institute of ENT. She completed
her MBBS from Dhaka Medical College and MD (Cli. Biochem) at Bangabandhu Sheikh Mujib Medical University. She joined government job after qualifying
BCS (health) in 1995. Since then, she served at different Thana Health Complexes in different districts. She also served at Medical Colleges and Institutes like
Dhaka, Sir Salimullah, Faridpur Medical College and NIDCH. She has a number of publications at national level. She is the Press and Publication Secretary of
running Executive Committee of Bangladesh Society of Medical Biochemists and also the Executive Editor of Bangladesh Journal of Medical Biochemistry. She
is a Member of Human Genome Organization. She was trained in Medical Biotechnology. As a member of organizing committee she arranged different national
conferences of BSMB.
humairabasad@yahoo.comHumaira Binte Asad et al., J Clin Nutr Diet 2019, Volume 05