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Journal of Medical Physics and Applied Sciences
ISSN: 2574-285X
I n t e r n a t i o n a l C o n f e r e n c e o n
Nuclear Medicine &
Radiation Therapy
Nuclear Medicine & Radiation Therapy 2018
O c t o b e r 0 1 - 0 2 , 2 0 1 8
S t o c k h o l m , S w e d e n
EPR protocol for dose delivery in radiotherapy/radiosurgery
Catalin Stelian Tuta1 , Marie Noelle Amiot2, Jean Marc Bordy2 ,
Valentin Blideanu 2, Loic de Carlan2 , Sorin Bercea1 and Mihail
Razvan Ioan1
1Horia Hulubei National Institute for R&D in Physics and Nuclear Engineering (IFIN-HH), Romania
2LNE -LNHB, CEA Saclay Center, France
Biography
Catalin Stelian Tuta has completed his PhD from Faculty of
Chemistry, University of Bucharest. Currently, he is working as
a Scientific Officer at National Institute of Physics and Nuclear
Engineering (IFIN-HH). He has published more than 10 papers
in various scientific journals.
Thereare fourmillionnewcasesof cancer per year, and thenumber of treatments
is also increasing due to diagnostic improvements and an ageing population.
The goal of radiotherapy/radiosurgery is to kill the tumour cells and simultaneously
achieve a high survival rate of the surrounding healthy tissue. A 5% change in the
dose can result in normal tissue complication probability of 20%-30%. However,
the uncertainty requirement for the dose to the tumour (2.5% ICRU) is not achieved
due the gap between the calibration conditions and the conditions used for new
treatment modalities based on small and complex radiation fields. Electron
paramagnetic resonance (EPR)/electron spin resonance (ESR) spectroscopy is a
suitable method for radiation dosimetry due to its accuracy, sensitivity and non-
destructive measuring procedure. Materials in which stable paramagnetic species
are produced by irradiation can be used as EPR dosimeters for radiation research.
When the relationship between EPR signal intensity of stable paramagnetic centre
and the dose is of linear character over a wide dose range, the material can be
used as a good dosimeter. The amino acid alanine (CH 3 (NH2)-CH-COOH) is one
of the most standardized organic materials for fabrication of dosimeters. The
alanine dosimeters are used in biomedical applications due to the similarity with
human tissues. Alanine dosimeters are small, compact and quite easy to handle.
They are characterized by low influence of dose rate as well as a wide measuring
dose range, which makes them applicable for radiation therapy in the ~5-100 Gy
dose range where the measured signal is proportional to the absorbed dose. In
this paper, an optimisation of the operational parameters of the EPR spectrometer
was performed in order to determine the range of doses used in radiotherapy/
radiosurgery using alanine dosimeters system and as a result, a new improved
protocol was developed.
Catalin Stelian Tuta et al., J. med phys & appl sci 2018, Volume: 3
DOI: 10.21767/2574-285X-C1-002