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ISSN:2171-6625
September 18-19, 2017 | Dallas, USA
4th International Conference on
NEUROLOGY AND NEUROIMMUNOLOGY
Neurological complications of Gluten Fibromyalgia
Dmitriy Labunskiy
University of Northern California, USA
Fibromyalgia (FM) is a complex chronic pain syndrome
that affects about 2% of the population, mainly
women, from all over the world, and is characterized by
widespread pain in soft tissues, generalized sensory points,
pathological fatigue and sleep disturbances. Celiac disease
is a multisystem autoimmune disease that occurs as a result
of gluten intolerance and affects 1-2% of the population,
mostly women. The relationship of individual parameters
with the presence of FM in patients of the main group and
the comparison group was characterized by the presence
of similar traits and differences. In particular, there was a
coincidence of the fact and direction of the relationship of
FM and parameters such as RLS, depression, anxiety. The
relationship of FM with polyneuropathy of thin and thick
fibers was noted only in patients with celiac disease, and
the relationship of FM with migraine only in the comparison
group. The study showed that the prevalence of FM in
patients with celiac disease is three times higher than in
the population. The typical form of celiac disease and the
age of patients 40-59 years are prognostic unfavorable signs
of the development of FM in patients with celiac disease.
Qualitative signs of FM in patients with celiac disease did not
have any specific features: statistically significant differences
in both groups by such features as the number of sensitive
points, the duration of FM in months, the number of points
on the FM questionnaire were absent (p> 0.05). Both FM and
celiac disease are often undiagnosed diseases, typical of any
gender and age. FM is often combined with diseases of the
gastrointestinal tract. In this study, the frequent occurrence
of FM in patients with celiac disease was identified. It is
necessary to exclude FM in patients with celiac disease. The
dependence of FM on polyneuropathy of fine fibers, restless
leg syndrome, depression, anxiety in the group of patients
with celiac disease was revealed. One of the modern
methods for diagnosing polyneuropathy of fine fibers in
patients with FM is the immune-histochemical study of skin
biopsy specimens on C-fibers by means of antibodies to the
protein gene product 9.5.
Speaker Biography
Dmitriy Labunskiy graduated wish M.D. from the Medical School of the Moscow State
University in 2002. After his graduation he worked at the Research Center of Neurology
inMoscowworking upon project on Neuroimmunology in Neurodegenerative Diseases.
He have got his Ph.D. upon defending his thesis of Immune State, Neurospecific
Proteins and Antibodies in Hereditary Spino-Cerebellar Ataxias. From 2008 he works at
the University of Northern California in Petaluma, CA on a number of research project
in Neuroimmunology.
e:
Dmitriy Labunskiy, J Neurol Neurosci, 8:5
DOI: 10.21767/2171-6625-C1-002