neuroimmunology-2017-scientifictracks-abstracts

13 / 13

Page 36
ISSN:2171-6625
September 18-19, 2017 | Dallas, USA
4th International Conference on
NEUROLOGY AND NEUROIMMUNOLOGY
Various types of immune system abnormalities were
detected in children with autism, such as higher
expression of plasma pro-inflammatory cytokines and
increased levels of antibodies against brain, central nervous
system and maternal proteins. These findings confirm the
role of endocannabinoid (EC) system in orchestrating the
peripheral and central neuro-immunologically mediated
effects in autism. Current pharmacological approaches
for autism are directed at symptoms, rather than the
underlying pathogenesis. The newest studies suggest
that pharmacological modulation of the EC system could
represent a novel approach for autism treatment. Among
the potential EC system targets, modulation of cannabinoid 2
(CB2) receptor signalling, could offer a promising therapeutic
target with minimal psychotropic effects. In the first part of
the lecture, history of cannabis use for medicinal purposes,
along with details regarding discovery, and functional role
of EC system are described. In a second part of the lecture,
special attention will be given to CB2 receptor, its expression
pattern in human and animal tissues, and the signalling
pathways induced by its activation. The role of CB2 receptors
in neurodevelopment and immunomodulation will be
considered in the third part. The last part of the presentation
will review current pharmacological strategies in targeting
CB2 receptors in patients with autism.
Speaker Biography
Zoran M Pavlovic MD, got his medical degree at the age of 25, completed his residency
and obtained board certification in Psychiatry, from School of Medicine in Belgrade,
Serbia. He has published numerous articles in the US (Journal of Neuropsychiatry and
Clinical Neurosciences, Primary Care Companion to the Journal of Clinical Psychatry,
Journal of Clinical Psychopharmacology) and European neuropsychopharmacology
journals (International Journal of Neuropsychopharmacology and European Psychiatry).
He serves as National Advisor at the European College of Neuropsychopharmacology
(ECNP) and is a Member of the International College of Neuropsychopharmacology
(CINP). He is currently working as Medical Director Psychiatry with PRA International
in Germany.
e:
Correlation link between immune system abnormalities and cannabinoid receptors 2 (CB2) signal
dysregulation in autism: novel approach in autism research and treatment
Zoran M Pavlovic
Neuroscience and Mental Health Services Belgrade, Serbia
Zoran M Pavlovic, J Neurol Neurosci, 8:5
DOI: 10.21767/2171-6625-C1-002