heart-world-cardiology-2019-scientifictracks

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Interventional Cardiology Journal

ISSN: 2471-8157

n d

E d i t i o n o f E u r o S c i C o n C o n g r e s s o n

Heart Disease and

Interventional Cardiology

F e b r u a r y 2 5 - 2 6 , 2 0 1 9

P a r i s , F r a n c e

Heart and World Cardiology 2019

athogenesis of atherosclerosis and the search for novel therapies and

diagnostic markers remain major problems of modern medicine. Currently

available therapeutic approaches are often not sufficiently effective, probably

due to the complexity of the disease mechanisms. This review focuses on the

evaluation of low-density lipoprotein (LDL) as risk factors of atherosclerosis.

We summarize the current paradigm of LDL involvement in atherogenesis.

We question the currently widely accepted hypothesis of the central role of

oxidized LDL in atherogenesis and present an alternative concept of multiple

modification of LDL that confers its pro-atherogenic properties. According to

a series of studies conducted with blood serum and LDL from atherosclerotic

patients, desialylation is one of the earliest if not the rst atherogenic

modi cation of LDL. Desialylation occurs in the bloodstream and is followed by

a cascade of other modi cations, including the reduction of LDL particle size

and increase of its density, acquisition of negative electrical charge, oxidation

and formation of highly atherogenic complexes. This work was supported by

the Russian Science Foundation (Grant # 18-15-00254).

Biography

Alexander N. Orekhov has completed his PhD at the age of

29 years from Moscow State University and second doctoral

degree (DSc) from Institute of Experimental Medicine (St.

Petersburg). He is the head of laboratory of Institute of General

Pathology and Pathophysiology. He has published more than

400 papers in reputed journals and has been serving as an

editor-in-chief, guest editor and editorial board member of

several biomedical journals.

Desialylated Atherogenic Low-Density Lipoprotein in

Atherosclerosis

Alexander N. Orekhov, Veronika A. Myasoedova

Institute of General Pathology and Pathophysiology, Moscow, Russia

Alexander N. Orekhov et al., Interv Cardiol J 2019, Volume: 5

DOI: 10.21767/2471-8157-C1-005