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Interventional Cardiology Journal
ISSN: 2471-8157
2
n d
E d i t i o n o f E u r o S c i C o n C o n g r e s s o n
Heart Disease and
Interventional Cardiology
F e b r u a r y 2 5 - 2 6 , 2 0 1 9
P a r i s , F r a n c e
Heart and World Cardiology 2019
Introduction:
Reactive oxygen species (ROS) are responsible for generalized oxidation
which results in cell dysfunction, necrosis or apoptosis. Assessment of oxidative stress
markers could modify prevention, risk stratification and treatment of patients with
coronary artery disease (CAD). The aim of this study was to evaluate association of
biomarkers of oxidative stress, stress glycaemia and glycated hemoglobin (HgbA1c)
with CAD.
Methods:
Cross-sectional observational study was performed in hospitalized CAD
patients. Beside their demographics, risk factors and co-morbidities, lipoprotein profile,
glycemic profile and oxidative stress biomarkers: malondialdehyde (MDA) and hydro
peroxide (HP), and antioxidant enzymes: superoxide dismutase (SOD), CATALASE and
glutathione peroxidase (GPS) were measured. Comparison was performed between
CAD patients and healthy controls, patients with acute coronary syndrome (ACS) versus
chronic CAD (inside the group: between PCI revascularised and stable post MI patients)
and ACS patients (STEMI, NSTEMI and unstable angina).
Results:Study included 300 patients, (64.7% males and 36.3% females), mean age
of 62.9±11,2 years. (p=ns between genders for age). 187 (62.3%) were ACS and 113
(37.7%) chronic CAD patients. There was no statistical significant difference in the risk
profile between the CAD groups. Patients with CAD had significantly higher pro-oxidative
and significantly lower anti-oxidative levels of biomarkers (Table 1), as compared with
healthy volunteers. Statistically significant differences were observed for HP and SOD
between ACS and HCAD group. In HCAD group, revascularized patients demonstrated
higher oxidative stress as compared to stable post MI patients. In ACS patients statistical
significant intergroup difference was registered, but not pointing to the single type of
ACS. ACS patients had also higher levels of stress glycaemia and HgbA1c. Significant
positive correlation were found for HgbA1c and stress glycaemia with MDA (r=,154**,
p=0,008; r=,254**, p=0,024 respectively).
Conclusion:
CAD patients demonstrated pronounced oxidative stress when compared
to healthy controls. Respectively, ACS patients had higher oxidative stress as compared
with chronic CAD patients, where PCI vascularized sub-group of patients performed
worse that stable post MI patients. Higher oxidative stress activity was linked to worse
glycemic control as measured threw stress glycaemia and HbA1c
Biography
Marija Vavlukis has completed her PhD at the age of 44 years
fromSs’ Cyril andMethodius University, Medical Faculty, Skopje,
Republic of Macedonia. She is Head of ICCU at the University
Clinic of Cardiology, National coordinator of The American-
Austrian Foundation-Open Medical institute, national champion
in ACCA of The European Society of Cardiology, FESC since
2016. She is also a Professor at faculty of Medical Sciences at
Goce Delcev University, mentoring PhD students and residents
in cardiology. She has publishedmore than 60 papers in reputed
journals, participated at national/international congresses,
symposiums, workshops, other meetings with plenary or oral
presentations in more than 40 occasions, and authored or co-
authored more than 150 publications. She has been serving as
an editorial board member and reviewer in several Journals of
repute.
marija.vavlukis@gmail.comAbstract Title: Association of biomarkers of oxidative stress,
stress glycaemia and glycated haemoglobin with Coronary
Artery Disease
Marija Vavlukis
University Clinic of Cardiology, Republic of Macedonia
Marija Vavlukis, Interv Cardiol J 2019, Volume: 5
DOI: 10.21767/2471-8157-C1-005