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E u r o p e a n C o n g r e s s o n
Vaccines & Vaccination
and Gynecologic Oncology
Vaccines & Vaccination and Gynecologic Oncology 2018
O c t o b e r 2 6 - 2 7 , 2 0 1 8
B u d a p e s t , H u n g a r y
Critical Care Obstetrics and Gynecology
ISSN: 2471-9803
Biography
Charulata has completed her PhD and she is senior consultant
embryologist at Yashoda Fertility and Research Institute, Hyder-
abad, India. She has a 18 long years’ experience in field of ART.
She keeps herself updated with recent advances in ART and
regular in writing Abstracts, Posters, Oral paper presentations
in national and international forum.
charulata88@gmail.comOutcome of HIC and ICSI on sibling oocytes for male sub fertility
Chraulata Chatterjee and Papolu Rama Devi
Yashoda Fertility and Research Institute, India
Dr. Rama's Institute for Fertility, India
Objective:
To follow up the outcome of sibling oocytes subjected to high
insemination concentration (HIC) and intracytoplasmic sperm injection (ICSI) in
the first cycles of male sub fertility with normal spermmorphology ≤4%
Design:
Randomized study
Patient(s):
26 couples undergoing first cycle of IVF-ICSI
Intervention(s):
Performing IVF with HIC and ICSI on sibling oocytes
Main outcome measure(s):
Fertilization and pregnancy rate
Result(s):
A controlled comparison between IVF-HIC and ICSI was made for 26
patients with ≤ 4% normal sperm morphology and ≥10x10
6
motile spermatozoa
per semen preparation. Female partner’s age was 31±3.1 and day 3 FSH was
7.9±1.1. HIC procedure involved insemination under micro droplets with sperm
concentration 2-5 fold higher than standard IVF. ICSI was done as per available
standard procedure. A total of 316 oocytes were retrieved from 26 pickups. 182
were subjected to ICSI and 143 MII oocytes were micro manipulated and 134 were
subjected to HIC. Fertilization rate between ICSI and HIC was 88.8% (127/143)
and 80.5% (108/134). The pregnancy rate in the two groups was 44% (6/14) and
41.6% (5/12).
Conclusion:
The present study offered HIC as an initial form of treatment for
male sub fertility, as long as ICSI remains more expensive and required skillful
embryologist. However, the use of sibling oocytes for ICSI is recommended,
especially in cases with <4% normal spermmorphology.
Chraulata Chatterjee et al., Crit Care Obst & Gyne 2018, Volume: 4
DOI:10.21767/2471-9803-C1-002