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Journal of Infectious Diseases and Treatment
ISSN: 2472-1093
7
t h
E u r o s c i c o n C o n f e r e n c e o n
Clinical Pathology
and Epidemiology
F e b r u a r y 2 7 - 2 8 , 2 0 1 9
P r a g u e , C z e c h R e p u b l i c
Clinical Pathology & Epidemiology 2019
Introduction and Objective:
Polychlorinated biphenyls (PCBs) have been
used commercially since 1929 as dielectric and insulating non-flammable
substances, additives for paints, petc. In Slovakia, 60 chemical production
workers highly exposed to PCBs (mainly to Delor 103) were studied with
duration of exposure ranging from 3 months to 19 years.
Materials and Methods:
Clinical examinations of skin, skin histology and
laboratory tests concerning lipid metabolism, iron metabolism and levels of
copper provided comparisons with a control group of healthy individuals and/
or the upper limits of normal values.
Results:
Skin changes were found in 47 % of individuals. In most cases milia-
like efflorescences (57.14 %) occurred, as well as comedones (55.35 %);
other symptoms occurred in a smaller number. Hyperkeratosis, acanthosis
of the epidermis (particularly in hair follicles) and a cellular infiltration of the
corium were all found through histology. The intensity of cutaneous affections
was associated with the changes in laboratory tests. Elevated triglycerides,
cholesterol, and phospholipids were found in exposed workers. After a
further two years, a significant increase in triglycerides was found in exposed
individuals when compared with the control group. In addition, a significant
increase in serum levels of copper, and total and unsaturated iron-binding
capacity was detected.
Conclusions:
Anamnesis showed that some people occupationally exposed to
PCBs may develop skin changes after three months of excessive occupational
exposure. The results represent a unique snapshot of worker exposure to on
given location, representing the basis for comparison with population grew up
in the area and live there to this day.
Retrospective assessment of specific effects of occupational
exposure of workers to PCBs in Slovak Republic
Tatiana Kimakova
1
, Boshra Nasser
1
, Marwan Issa
1
, Vladimir Bencko
2
1
Faculty of Medicine, Pavol Jozef Safarik University, Slovakia
2
Charles University, Prague Czech Republic
Tatiana Kimakova et al., J Infec Dis Treat 2019, Volume: 5
DOI: 10.21767/2472-1093-C1-009
Biography
Associate Professor DVM Tatiana Kimáková, PhD. – published
over 370 papers, presented over 160 scientific and scientific
lectures home and abroad, more than 230 citations. Professor
MUDr. Vladimír Bencko, DrSc. – from 1990 he was the head of
the Institute of Hygiene and Epidemiology of the 1st Medical
Faculty of Charles University, his written output remains prolific,
with 226 WoS registered publications and a citation index of
5804 and h-index of 39
tatiana.kimakova@upjs.sk