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Page 31
Biochemistry & Molecular Biology Journal
ISSN: 2471-8084
Internat i ona l Conference on
Biotechnology, Biomarkers
& Systems Biology
M a r c h 0 4 - 0 5 , 2 0 1 9
Am s t e r d a m , N e t h e r l a n d s
Biotechnology, Biomarkers & Systems Biology 2019
T
his protein has several interesting biological effects including
detoxification of heavy metals like mercury and cadmium, homeostasis
of essential metals including copper and zinc, antioxidation against reactive
oxygen species, protect against DNA damage, oxidative stress, cell survival,
angiogenesis, apoptosis, as well as increase proliferation etc,. Numerous
studies have been demonstrated increase focus on the role of MT in various
biological systems in the past three decades. The studies on the role of MT
were limited with few areas like apoptosis and antioxidants in selected organs
even fifty years after its discovery. We now acknowledge the exploration of MT
isomers such as MT-I, MT-II, MT-III and MT-IV in various biological systems and
disease conditions like diabetic, kidney dysfunction, sclerosis, cancer, bone
growth retardation, neuro toxicity etc in different organs (heart, CNS, kidney,
etc) were established in recent years to research further.
Introduction:
This article is an attempt to focus some of its important and
current finding of isomers of metallothionein role in the biological system
to explore in many new areas. The metallothionein (MT) was first isolated in
1957 from the cortex of horse kidney as a cadmium binding protein [1]. This
protein was first reported by Kagi and Vallee in 1960 and by Kojima in 1976 as
cysteine-rich (33 mol %), low molecular weight (7 kDa), heat-stable and metal
binding protein.
Discussion:
There are at least ten known closely related metallothionein
proteins expressed in the human body. In humans, large quantities are
synthesized primarily in the liver and kidneys, however they have been found
at a number of other sites as well. Its production is dependent on availability
of the dietary minerals zinc and selenium, and the amino acids histidine and
cysteine present in the body. This article conclude that, many independent
groups of investigators found direct casual relationships between MT and
pathophysiology but more pronounced reasons among those was endogenous
and exogenous stimuli including glucocorticoids, interferon, interleukin-1,
progesterone, vitamin D3 endotoxins, serum factors, heavy metals, storage of
metal ions and regulation of cellular zinc etc. may trigger the expression of MT
in human and animal's body.
Biography
N. Thirumoorthy is working as professor cum director in PPG
College of pharmacy Coimbatore India. He has 19 years of
teaching and 8 years of research experience in his field. He
completed his PhD at the age of 31 years from Jadvapur
University . He has more than 30 papers in reputed journals
at national and international level and has been serving as an
editorial boardmember of repute. He is guiding students of both
M.Pharm and Ph.D projects topics under various Universities
in Tamilnadu. he received many awards particularly the best
teacher award of the Tamilnadu Dr MGR Medical University
couple of years back.
professorthiru@gmail.comA Current Update of Metallothionein and its Isomers
Thirumoorthy N
1
and Senthilkumara
2
1
PPG College of Pharmacy Sathi Road, India
2
Pharms med Dubai
Thirumoorthy N et al., Biochem Mol biol J 2019, Volume:5
DOI: 10.21767/2471-8084-C1-023