Archives in Cancer Research

Department of Biomedical Sciences, University of Illinois College of Medicine, Rockford, Illinois, USA

Ashley Eggert being an eminent members at Department of Biomedical Sciences, University of Illinois College of Medicine, Rockford, Illinois, USA have a great interest towards Journal name and has worked for more than 10 years in the related field and gained a loads of knowledge in related field. His/Her working has been displayed at the international conferences and been published in journal proceedings.

Clinical Challenges to Current Molecularly Targeted Therapies in Lung Cancer

Lung cancer is difficult to treat with a poor prognosis and a five year survival of 15%. Current molecularly targeted therapies are initially effective in non-small cell lung cancer (NSCLC) patients; however, they are plagued with difficulties including induced resistance and small therapeutically responsive populations. This mini review describes the mechanism of resistance to several molecularly targeted therapies which are currently being used to treat NSCLC. The major targets discussed are c-Met, EGFR, HER2, ALK, VEGFR, and BRAF. The first generation tyrosine kinase inhibitors (TKIs) resulted in resistance; however, second and third generation TKIs are being developed, which are generally more efficacious and have potential to treat NSCLC patients with resistance to first generation TKIs. Combination therapies could also be effective in preventing TKI resistance in NSCLC patients.