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I n t e r n a t i o n a l C o n f e r e n c e o n
Neurological Disorders,
Stroke and CNS
October 22-23 , 2018
Athens , Greece
Journal of Neurology and Neuroscience
ISSN: 2171-6625
Stroke and CNS 2018
Neurocognitive disorders have been characterized by being a devastating long term neurological disease with a huge social
and economic impact. Alzheimer's disease (AD) is the most common type of dementia accompanied with decline in cognitive
functions.
Objectives:
The main aim of this study is to suggest therapeutic protocol having the potentials for restoring and modifying
neuropathological deposited hallmarks including both positive and negative lesions such as amyloid plaques, tau protein and
synaptic loss.
Materials & Methods:
Rats were divided into nine groups: (G1) control; (G2) rats received lipopolysaccharide (LPS) as a method
of inducing non-genetically manipulated neuroinflammatory AD type; (G3) AD rats received NaHS; (G4) AD rats received
mesenchymal stem cells (MSCs) intracerebrally; (G5) AD rats received MSCs+NaHS; (G6) AD rats received kefir+Ginko Biloba
(GB); (G7) AD rats received MSCs+ kefir+GB; (G8) AD rats received NaHS+ kefir+GB; (G9) AD rats received MSCs+NaHS+kefir+GB.
Results:
The induction of AD resulted in downregulation of cystathionine β-synthase enzyme (CBS) relative gene expression and
glutathione (GSH) brain tissue level accompanied with overexpression in amyloid-β protein, mitogen-activated protein kinases
(MAPK), tau protein, ACAT (Acyl-CoA cholesterol acyl transferase) relative gene expression and malondialdehyde (MDA) brain
tissue level in addition to elevated caspase-3 serum activity level.
Conclusion:
The present study clearly proved the beneficial role of NaHS as exogenous H2S donor in attenuating AD drawbacks
mainly through CBS/H2S overexpression, enhancing the degradation of Aβ deposited plaques in addition to the ability of MSCs
administrated locally to develop into different types of neural cells to compensate damaged ones. The role of administrating
Kefir and GB in maintaining normal brain functions suggested being as a result of their synergistic antioxidant and antiapoptotic
actions.
mainwr@hotmail.comThe neuroprotective and neuroregenerative
actions of hydrogen sulphide donor, intracerebral
MSCs, Ginko Biloba and Kefir in attenuating
neuropathological hallmarks of Alzheimer's disease
induced by lipopolysaccharide in rats
Mai M Anwar
1
, Ola S M Ali
2
, Laila A Rashed
3
, Badawi A M
1
and Nadia A Eltablawy
1
1
National Organization for Drug Control and Research (NODCAR), Egypt
2
Al Azhar University, Egypt
3
Cairo University, Egypt
J Neurol Neurosci 2018, Volume: 9
DOI: 10.21767/2171-6625-C3-015