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Polymer Chemistry 2018 Polymer Sciences
ISSN: 2471-9935 Page 51
March 26-28, 2018
Vienna, Austria
3rd Edition of International Conference and Exhibition on
Polymer Chemistry
Polyglycidol of hyperbranched architecture (HbPGL) is able
to interact with boronic acids thanks to vicinal diol groups
present in the peripheral area of the macromolecule. As a result,
injectable hydrogel systems can be formed at different pH
conditions. Bioinert and protein antifouling characteristics of
HbPGL makes hydrogels prepared from this polymer a suitable
system for biomedical applications. Hydrogel environment
turned out to be completely inert to alkaline phosphatase, which
facilitated triggering the biomineralization
Due to the fact that diffusion of reagents limits the rate of
enzymatic reactions within gel, the influence of polymer weigh
fraction and the length of cross-linking copolymer bearing boronic
acid on the diffusivity of encapsulated in hydrogel molecules was
estimated. The dynamics of macromolecules forming hydrogel
network was monitored based on their diffusion coefficients
using 1 H HR MAS DOSY NMR. Depending on the diffusivity, the
course of biomineralization within hydrogel was different. 1H
NMR DOSY NMR spectra, along with standard 1H NMR spectra,
were also used to monitor the behaviour in solution of another
type cross-link, which is a homodimer of molecular clips. By
making use of this affinity, we can prolong the macromolecule
of the polymer or generate the polymer network. The affinity
toward homodimerization is strictly dependent on the solvent,
temperature and on the presence of other compounds, which
can play the role of the guest molecules. Due to the fact that
homodimerization is driven both by π-π interactions and hydrogen
bonds formation, such solvents as DMSO prevents dimers
formation, whereas for example chloroform stimulates the self-
association of molecular clips.
Biography
Dr. Monika Gosecka is an adjunct in the Department of Engineering of Poly-
mer Materials in the Centre of Molecular and Macromolecular Studies,
Polish Academy of Sciences, CMMS PAS, Lodz. She obtained her PhD
degree in 2013 at the CMMS PAS for investigating the mechanism of
core-shell polymer particles formation and their properties. After PhD stud-
ies, she spent a one-year as a postdoc at École Supérieure de Physique et
de Chimie Industrielles de la Ville de Paris working on the project involving
vitrimer systems. Her current research interests include the formation of re-
versibly cross-linked hydrogels based on hyperbranched polyglycidol in view
of biomedical applications.
Boronic ester and homodimerization of molecular clips as
cross-link motifs in the reversible networks
Monika Gosecka
Polish Academy of Sciences, Poland
Monika Gosecka, Polym Sci, Volume 4
DOI: 10.4172/2471-9935-C1-008