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Polymer Chemistry 2018

Polymer Sciences

ISSN: 2471-9935

Page 51

March 26-28, 2018

Vienna, Austria

3

rd

Edition of International Conference and Exhibition on

Polymer Chemistry

P

olyglycidol of hyperbranched architecture (HbPGL) is able

to interact with boronic acids thanks to vicinal diol groups

present in the peripheral area of the macromolecule. As a result,

injectable hydrogel systems can be formed at different pH

conditions. Bioinert and protein antifouling characteristics of

HbPGL makes hydrogels prepared from this polymer a suitable

system for biomedical applications. Hydrogel environment

turned out to be completely inert to alkaline phosphatase, which

facilitated triggering the biomineralization

Due to the fact that diffusion of reagents limits the rate of

enzymatic reactions within gel, the influence of polymer weigh

fraction and the length of cross-linking copolymer bearing boronic

acid on the diffusivity of encapsulated in hydrogel molecules was

estimated. The dynamics of macromolecules forming hydrogel

network was monitored based on their diffusion coefficients

using

1

H HR MAS DOSY NMR. Depending on the diffusivity, the

course of biomineralization within hydrogel was different.

1

H

NMR DOSY NMR spectra, along with standard

1

H NMR spectra,

were also used to monitor the behaviour in solution of another

type cross-link, which is a homodimer of molecular clips. By

making use of this affinity, we can prolong the macromolecule

of the polymer or generate the polymer network. The affinity

toward homodimerization is strictly dependent on the solvent,

temperature and on the presence of other compounds, which

can play the role of the guest molecules. Due to the fact that

homodimerization is driven both by π-π interactions and hydrogen

bonds formation, such solvents as DMSO prevents dimers

formation, whereas for example chloroform stimulates the self-

association of molecular clips.

Biography

Dr. Monika Gosecka is an adjunct in the Department of Engineering of Poly-

mer Materials in the Centre of Molecular and Macromolecular Studies,

Polish Academy of Sciences, CMMS PAS, Lodz. She obtained her PhD

degree in 2013 at the CMMS PAS for investigating the mechanism of

core-shell polymer particles formation and their properties. After PhD stud-

ies, she spent a one-year as a postdoc at École Supérieure de Physique et

de Chimie Industrielles de la Ville de Paris working on the project involving

vitrimer systems. Her current research interests include the formation of re-

versibly cross-linked hydrogels based on hyperbranched polyglycidol in view

of biomedical applications.

[email protected]

Boronic ester and homodimerization of molecular clips as

cross-link motifs in the reversible networks

Monika Gosecka

Polish Academy of Sciences, Poland

Monika Gosecka, Polym Sci, Volume 4

DOI: 10.4172/2471-9935-C1-008