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Polymer Chemistry 2018

Polymer Sciences

ISSN: 2471-9935

Page 49

March 26-28, 2018

Vienna, Austria

3

rd

Edition of International Conference and Exhibition on

Polymer Chemistry

L

iposomes are widely used in medicine for encapsulation of

biologically active compounds. Multi-liposome assembly

composed of liposomes loadedwith different fillings could enable

controlleddeliveryofthemedicinesinadesirableratio.Inthiswork,

we suggest a universal approach for preparation of biodegradable

multiliposomal containers through electrostatic adsorption of

liposomes on the surface of polymer nanoparticles. Firstly, we

describe the preparation and properties of nanoconjugates with

the “core-shell” structure in which the micellar core from a block

copolymer of polylactide and polyoxyethylene is covered by a

monolayer of small unilamellar liposomes. It was shown that

one micelle could bind 5–6 anionic liposomes. The resulting

nanoconjugate was stable in a physiological solution with [NaCl]

= 0.15 M. At the same time, the nanoconjugate degraded, being

attacked by proteolytic enzymes, down to 10–15 nm particles,

that was accompanied by a complete release of the encapsulated

antitumor antibiotic doxorubicin into surrounding solution. In

the second part of the study, anionic liposomes were adsorbed

on the surface of cationic chitosan nanoparticles. Chitosan is a

commercially available polycationic biopolymer of natural origin

that is known for being biocompatible and biodegradable. Each

chitosan particle could adsorb up to 100 anionic liposomes.

The conjugates demonstrated stability towards dissociation

in physiological media. The complexes were biodegradable,

which eventually decomposed after addition of enzymes. It was

found that chitosan-liposome complex and the products of its

biodegradation were non-toxic in a wide range of concentrations.

Thus, the findings of this work seem to be promising in the field

of drug delivery. This work was supported by the Russian Science

Foundation (project no. 14-13-00255).

Recent Publications

1. Yaroslavov A A, Efimova A A, Rudenskaya G N, Melik-

Nubarov N S, Grozdova I D,

et al.

(2017) An electrostatic

conjugate composed of liposomes, polylysine and a

polylactide micelle: a biodegradability–cytotoxicity

relationship. Mendeleev Communications 27(3):299.

2. Sybachin A V, Zaborova O V, Efimova A A, Ballauff M and

Yaroslavov A A (2017) Electrostatic complexes of liquid

and solid liposomes with spherical polycationic brushes.

Polymer Science-Series C 59(1):60.

3. Efimova A A, Chvalun S N, Kulebyakina A I, Kozlova E V

and Yaroslavov A A (2016) Synthesis and properties of

conjugates involving liposomes, a linear polymer, and

the micelle of a polylactide–poly(ethylene glycol) block

copolymer. Polymer Science-Series A 58(2):172.

4. Efimova A A, Zaborova O V and Sybachin A V (2016)

Multiliposomal nanocontainers based on anionic solid

liposomes and spherical polycationic brushes. Materials

Science and Engineering 1(111):22.

5. Efimova A A, Sybachin A V, Chvalun S N, Kulebyakina A I,

Kozlova E V,

et al.

(2015) Biodegradable multiliposomal

containers. Polymer Science-Series B 57(2):140. 

Biography

Anna A. Efimova graduated from Faculty of Chemistry, M.V. Lomonosov

Moscow State University. In 1996 defended Ph.D. thesis. Since 1996- Re-

search Scientist, since 2008- Associate Professor at Polymer Department

of Moscow State University. In 2004 awarded with the certificate of honour

of the Ministry of Education. Author or co-author of more than 40 scientific

publications. Research interests are associated with the interaction of poly-

mers and interpolymer complexes with colloid and liposomal dispersions,

structural rearrangements in lipid bilayers under the polymer adsorption,

polymer-induced transport of small molecules through the lipid membrane,

adsorption of liposomes on the surface of (bio) colloids, biodegradable and

stimuli-sensitive multiliposomal containers for the immobilization of biolog-

ically active substances..

[email protected]

Nanocontainers based on biodegradable polymer and anionic

liposomes

Efimova A A, Mulashkin F D, Krivtsov G G, Melik-Nubarov N S, Grozdova I D,

Rudenskaya G N, Sybachin A V, Chvalun S N, Kulebyakina A I, Razuvaeva E V

and

Yaroslavov A A

Lomonosov Moscow State University, Russia

Efimova A A et al., Polym Sci, Volume 4

DOI: 10.4172/2471-9935-C1-008