Polymer Chemistry 2018
March 26-28, 2018
Edition of International Conference and Exhibition on
icro-sized giant vesicles are a possible artificial model of
biomembrane for cells and organelles, such as erythrocytes,
mitochondria, and chloroplasts based on the similarities in size
and structure. In recent years, a novel artificial biomembrane
model has been established using giant vesicles comprised
methacrylate-random-methacrylic acid) diblock copolymers. The
polymer giant vesicles had some similarities to biomembrane, not
only in size and structure but also in the formation mechanisms,
morphological transformation, membrane permeability, and
stimulus-responsiveness. This paper describes the preparation
amino groups on the hydrophilic shells through the nitroxide-
mediated photo-controlled/living radical polymerization (photo-
NMP)-induced self-assembly, with the aim of establishing an
artificial model more suitable to biomembrane. The giant vesicles
were prepared by the block copolymerization of a methacrylate
ester supporting an amino group and methyl methacrylate using
the photo-NMP technique in methanol at room temperature
by irradiation with a high-pressure UV lamp. The photo-NMP-
induced self-assembly produced spherical vesicles with the
hydrophilic phase of the amine-containing polymethacrylate
blocks and the hydrophobic core of the poly(methyl methacrylate)
blocks. The size and morphology of the vesicles were dependent
on the lengths of the hydrophilic and hydrophobic blocks of the
copolymers. It was found that the vesicles were pH-sensitive and
disrupted in an acidic solution. Their thermo-responsive behavior
will be also described.
1. E Yoshida (2017) Fabrication of anastomosed tubular
networks developed out of fenestrated sheets through
thermo responsiveness of polymer giant vesicles.
2. E Yoshida (2015) Enhanced permeability of rhodamine
B into bilayers comprised of amphiphilic random block
copolymers by incorporation of ionic segments in the
hydrophobic chains. Colloid Polym. Sci., 293: 2437.
3. E Yoshida (2015) PH response behavior of giant vesicles
comprised of amphiphilic poly(methacrylic acid)-block-
poly(methyl methacrylate-random-methacrylic acid).
Colloid Polym. Sci. 293: 649.
4. E Yoshida (2014) Morphology control of giant vesicles
by manipulating hydrophobic-hydrophilic balance
of amphiphilic random block copolymers through
polymerization-induced self-assembly. Colloid Polym.
5. E Yoshida (2013) Giant vesicles prepared by nitroxide-
mediated photo-controlled/living radical polymerization-
induced self-assembly. Colloid Polym. Sci. 291:2733
Eri Yoshida is an Associate Professor at Toyohashi University of Technology.
She received her Bachelor’s Degree in Education fromTokyo Gakugei Univer-
sity and her PhD in Polymer Engineering fromTokyo Institute of Technology.
After she obtained her PhD, she joined Kyoto Institute of Technology as an
Assistant Professor. She also worked as a Visiting Scientist at the University
of North Carolina at Chapel Hill. She has more than 100 peer reviewed sci-
entific publications and 24 patents. She is a Member of the Editorial Board
of some international journals. Her research interests include molecular
self-assembly of amphiphilic copolymers, controlled/living radical polymer-
ization, and macromolecular design using supercritical carbon dioxide.[email protected]
Giant vesicles supporting amino groups on the hydrophilic shells
prepared by photo-controlled/living radical polymerization-
induced self-assembly of amphiphilic block copolymers
Toyohashi University of Technology, Japan
Eri Yoshida, Polym Sci, Volume 4