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Polymer Chemistry 2018

Polymer Sciences

ISSN: 2471-9935

Page 46

March 26-28, 2018

Vienna, Austria

3

rd

Edition of International Conference and Exhibition on

Polymer Chemistry

M

icro-sized giant vesicles are a possible artificial model of

biomembrane for cells and organelles, such as erythrocytes,

mitochondria, and chloroplasts based on the similarities in size

and structure. In recent years, a novel artificial biomembrane

model has been established using giant vesicles comprised

of

amphiphilic

poly(methacrylic

acid)-block-poly(methyl

methacrylate-random-methacrylic acid) diblock copolymers. The

polymer giant vesicles had some similarities to biomembrane, not

only in size and structure but also in the formation mechanisms,

morphological transformation, membrane permeability, and

stimulus-responsiveness. This paper describes the preparation

andmorphologicaltransformationofnewgiantvesiclessupporting

amino groups on the hydrophilic shells through the nitroxide-

mediated photo-controlled/living radical polymerization (photo-

NMP)-induced self-assembly, with the aim of establishing an

artificial model more suitable to biomembrane. The giant vesicles

were prepared by the block copolymerization of a methacrylate

ester supporting an amino group and methyl methacrylate using

the photo-NMP technique in methanol at room temperature

by irradiation with a high-pressure UV lamp. The photo-NMP-

induced self-assembly produced spherical vesicles with the

hydrophilic phase of the amine-containing polymethacrylate

blocks and the hydrophobic core of the poly(methyl methacrylate)

blocks. The size and morphology of the vesicles were dependent

on the lengths of the hydrophilic and hydrophobic blocks of the

copolymers. It was found that the vesicles were pH-sensitive and

disrupted in an acidic solution. Their thermo-responsive behavior

will be also described.

Recent Publications

1. E Yoshida (2017) Fabrication of anastomosed tubular

networks developed out of fenestrated sheets through

thermo responsiveness of polymer giant vesicles.

ChemXpress 10(1):118.

2. E Yoshida (2015) Enhanced permeability of rhodamine

B into bilayers comprised of amphiphilic random block

copolymers by incorporation of ionic segments in the

hydrophobic chains. Colloid Polym. Sci., 293: 2437.

3. E Yoshida (2015) PH response behavior of giant vesicles

comprised of amphiphilic poly(methacrylic acid)-block-

poly(methyl methacrylate-random-methacrylic acid).

Colloid Polym. Sci. 293: 649.

4. E Yoshida (2014) Morphology control of giant vesicles

by manipulating hydrophobic-hydrophilic balance

of amphiphilic random block copolymers through

polymerization-induced self-assembly. Colloid Polym.

Sci. 292:763.

5. E Yoshida (2013) Giant vesicles prepared by nitroxide-

mediated photo-controlled/living radical polymerization-

induced self-assembly. Colloid Polym. Sci. 291:2733

Biography

Eri Yoshida is an Associate Professor at Toyohashi University of Technology.

She received her Bachelor’s Degree in Education fromTokyo Gakugei Univer-

sity and her PhD in Polymer Engineering fromTokyo Institute of Technology.

After she obtained her PhD, she joined Kyoto Institute of Technology as an

Assistant Professor. She also worked as a Visiting Scientist at the University

of North Carolina at Chapel Hill. She has more than 100 peer reviewed sci-

entific publications and 24 patents. She is a Member of the Editorial Board

of some international journals. Her research interests include molecular

self-assembly of amphiphilic copolymers, controlled/living radical polymer-

ization, and macromolecular design using supercritical carbon dioxide.

[email protected]

Giant vesicles supporting amino groups on the hydrophilic shells

prepared by photo-controlled/living radical polymerization-

induced self-assembly of amphiphilic block copolymers

Eri Yoshida

Toyohashi University of Technology, Japan

Eri Yoshida, Polym Sci, Volume 4

DOI: 10.4172/2471-9935-C1-008