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PCOS 2018 Journal of Clinical and Molecular Endocrinology
ISSN: 2572-5432 Page 21
June 07-08, 2018
London, UK
4th World Congress on
Polycystic Ovarian
Syndrome
As the management for women with polycystic ovary
syndrome (PCOS), Japan Society of Obstetrics and
Gynecology recommends a treatment using oral contraceptive
(OC) or progestin, prior to desiring pregnancy because PCOS
is a progressive disease. However, in Japan, OC-users for
contraception are only 3%, which means that OC is not a
familiar treatment amongst Japanese people. Recently, a
medicine consisting of low-dose estrogen-progestin (LEP)
became available for the treatment of dysmenorrhea, covered
with National Health Insurance. Moreover, a tablet containing
much lower hormone doses (Lunabell ULD: ethinyl-estradiol
0.02mg/norethisterone 1mg, Nobelpharma Co.) is widely used.
For the management of PCOS women, the effects of OC, LEP,
and conventional Kaufmann therapy (conjugated estrogens/
progestin) were evaluated from the viewpoints of improvement
of gonadotropins (luteinizing hormone (LH) and follicle-
stimulating hormone (FSH)) and androgen secretion. The side-
effects such as irregular genital bleeding, digestive symptoms,
and liver function were compared among those medicines. By
indicating our results, we can discuss a better way to prepare
the future childbearing among PCOS women.
Biography
Nobuhiko Suganuma—MD, PhD—is a Professor in the Department of Hu-
man Health Sciences, Kyoto University Graduate School of Medicine in Ja-
pan. He is the Director of Japan Societies of Fertilization and Implantation,
Maternal Health, Reproductive Psychology, and Sexual Science. He is also
the Councilor of Japan Society of Reproductive Medicine, and Japan Endo-
crine Society. Recently, he became the President of Japan Society for Uter-
us Transplantation (JSUTx), and a Vice President of International Society
of Uterus Transplantation (ISUTx), specializing in Uterine Factor Infertility
Treatment. As a Reproductive Endocrinologist, he demonstrated that the
PCOS occurrence could be connected with LH gene variation using molec-
ular biological technologies. Based on this work, he received the Research
Award from the Japan Endocrine Society in 1996. Based on the clinical as-
pects, his group could succeed the first childbirth in Japan in 1994 using
TESE-ICSI method. He has established a Center for Advanced Reproductive
Medicine in Kyoto University Hospital in 2013, and is performing cryopreser-
vation of oocytes or ovarian tissues as oncofertility management.
Management for women with PCOS prior to desiring pregnancy
Nobuhiko Suganuma and Ayako Hayashi
Kyoto University Graduate School of Medicine, Japan
Nobuhiko Suganuma et al., J Clin Mol Endocrinol 2018, Volume 3
DOI: 10.21767/2572-5432-C1-002