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PCOS 2018 Journal of Clinical and Molecular Endocrinology
ISSN: 2572-5432 Page 19
June 07-08, 2018
London, UK
4th World Congress on
Polycystic Ovarian
Syndrome
S moking in women impairs fecundity at some stages of
reproductive process including folliculogenesis, embryo
transport, endometrial angiogenesis, and uterine blood flow.
Yet little is known about the hazards of second-hand smoke
(SHS) exposure in women with PCOS. This is a secondary
analysis of the Polycystic Ovary Syndrome Acupuncture and
Clomiphene Trial (PCOSAct), a large randomized controlled
trial conducted at 27 hospitals from 2012 to 2015 in mainland
China. Out of 1,000 women with PCOS, SHS exposure status
were available in 500 women, of whom 271 women were
non-exposed, and 229 exposed to cigarette smoke (170≤10
cigarettes per day as low-SHS exposed and 59>10 cigarettes
per day as high-SHS exposed). We compared circulating sex
steroids, glucose and lipid metabolism, metabolic syndrome
and phenotypes, fertility and obstetric outcomes between
non-exposed and exposed women. Women exposed to SHS,
compared to non-exposed women, had a higher serum total
testosterone (1.7 vs 1.5 nmol/L, P=0.01), free androgen
index (5.7 vs 4.0, P=0.001) and lower sex hormone binding
globulin (30.1 vs 35.6 nmol/L, P=0.03). Metabolic syndrome,
but not other phenotypes, was more frequent in exposed
women as compared to non-exposed women (21.8% vs 13.3%,
adjusted OR=1.66; 95% CI, 1.02–2.71, P=0.04). Ovulation
rates between exposed and non-exposed groups were not
significantly different (76.9% vs 82.9%, adjusted OR=0.72; 95%
CI, 0.45–1.15, P=0.17). Conception rates were significantly
lower in exposed group (26.6% vs 36.9%; adjusted OR=0.61;
95% CI, 0.41–0.91; P=0.01), while clinical pregnancy and live
birth rates showed a similar trend that was not significantly
different. Gestational age, birth weight and other obstetric
outcomes were not affected by SHS exposure. In conclusion,
SHS exposure is associated with worsened biochemical
hyperandrogenism, higher incidence of metabolic syndrome
and reduced conception rates in women with PCOS. These
data suggest that smoking partners of infertile women with
PCOS who seek treatment should be advised to quit smoking.
Biography
Ronald Wang is currently Professor at the Department of Obstetrics & Gy-
naecology; Deputy Director, Prenatal Genetics Diagnosis Centre; Laborato-
ry-in-charge, Department of Obstetrics & Gynaecology; Professor (by cour-
tesy), School of Biomedical Sciences; and Principal Investigator, Li Ka Shing
Institute of Health Sciences, The Chinese University of Hong Kong. His
major research interests are in clinical and basic research in reproductive
medicine, and he has been recently involved in a RCT on PCOS. With a wide
range of experience in clinical diagnosis, medical research and teaching, he
was appointed to the Editorial Boards and ReviewPanels of many important
research funding agents and journals. He has worked on many research
projects, received a total of 60 million research grants and owns two pat-
ents. He has published over 150 ISI articles in many acclaimed journals.
Effect of exposure to second-hand smoke from husbands on
sex hormones, metabolic profiles, clinical phenotypes and
pregnancy outcomes in women with polycystic ovary syndrome
undergoing ovulation induction
Ronald Wang1, Ricky Qi Wu1, Jian Li2 and Xiao-Ke Wu2
1The Chinese University of Hong Kong, Hong Kong
2Heilongjiang University of Chinese Medicine, China
Ronald Wang et al., J Clin Mol Endocrinol 2018, Volume 3
DOI: 10.21767/2572-5432-C1-002