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Wen-Jun Shen

Wen-Jun Shen
Division of Endocrinology, Gerontology and Metabolism, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA


I have broad background in molecular and cell biology with specific training and expertise in key research areas in proteins/pathways for insulin secretion and lipid metabolism. Throughout my career as research scientist, I have worked on various components in controlling lipid droplet metabolism. These include lipases, lipid droplet associated proteins as well as their interacting proteins in adipose tissue, liver and steroidogenic tissue. Recent work also involves the study of trafficking of high density lipoprotein by scavenger receptor class B type I (SR-BI) expression and function in steroidogenic cells and hepatocytes and attenuation of metabolic dyslipidemia in experimental rodents. Currently, I am also working on the exploration of lipid signals in controlling adipogenesis and osteoblastogenesis during aging, and shown that decreased adipogenesis by inhibiting HSL could aid in maintain high bone volume during aging process.

Research Interest

Biochemistry, Molecular Biology, Insulin secretion, Lipid Droplet Metabolism and Physiology of disturbed lipid homeostasis