Chungnam National University (Daejeon, Korea)
Man-Ho Oh, PhD is Professor of Department of Biological Sciences, Chungnam National University. He earned Ph degree at the Seoul National University (Seoul, Korea), After that he followed by the postdoctoral fellowships in plant molecular biology and Brassinosteroid signal transduction at the North Carolina State University, Raleigh NC (USA). Professor Steve D. Clouse?s research is plant molecular biology and biochemistry wit applications to horticultural crops, including regulation of plant gene expression during development; molecular mechanisms of plant hormone action, particulary brassinosteroids (BR), and proteomics. He identified the first BR-insensitive mutant, bri1, which is a hallmark in plant BR research. Dr. Man-Ho is involved in many BR-related research with him since 1995. Dr. Man-Ho is Associate Editor in Genes & Genomics, J. Plant Biotechnology, and Translational Genetics and Genomics.
Plants respond to developmental and environmental signals in part through membrane-localized receptor kinases that interact with other proteins to initiate a cascade of biochemical events resulting in altered cellular function. The genome of the model plant Arabidopsis and Brassica rapa and B. oleracea encodes several hundred Leucine-Rich Repeat Receptor-Like Kinases (LRR RLKs) with a structural organization similar to that of animal receptor kinases. Several of these plant LRR RLKs have been characterized in some detail and are known to play critical roles in regulating growth, morphogenesis, disease resistance, and responses to stress signals. Key to understanding LRR RLK action in specific signaling pathways is the identification of both membrane-bound and soluble protein partners.
The major focus in my laboratory is on identification of biological mechanisms that regulate important plant processes and impact growth and development. Studies include several levels but most work is focused on post-translational mechanisms including plant molecular genetics, protein biochemistry and plant proteomics. One such mechanism that plays an important role in the regulation of enzyme activity, but is still poorly understood in plant systems, is reversible protein phosphorylation. Each of the processes we are studying involves at least one enzyme that is phosphorylated.