Jennifer A. DollDepartment of Biomedical Sciences, University of Wisconsin Milwaukee, USA
Biography
Dr. Doll received her Ph.D. in Molecular Genetics at Washington University, conducted a post-doctoral
fellowship in the tumor angiogenesis at Northwestern University, and is currently an Associate Professor
in the Department of Biomedical Sciences at the University of Wisconsin Milwaukee. Since 1993, her
research focus has been prostate cancer (PCa). In particular, she has focused on two tumor suppressor
proteins, pigment epithelium derived factor (PEDF) and thrombospondin-1 (TSP-1), both of which are
potent anti-angiogenic agents. Interestingly, both also function in regulation of lipid metabolism. Obesity
has reached epidemic levels in the United States, affecting nearly 30% of the population, and it is
evident that excess adipose tissue fuels PCa. However, the molecular mechanisms contributing to
obesity-driven PCa are largely unknown. Dr. Doll?s research focuses on understanding how the
functions of PEDF and TSP-1 are altered in an obese PCa microenvironment, with the goal of identifying
novel targets for PCa therapy.
Research Interest
Dr. Doll?s research focuses on understanding how the
functions of PEDF and TSP-1 are altered in an obese PCa microenvironment, with the goal of identifying
novel targets for PCa therapy.