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PCOS 2018
Journal of Clinical and Molecular Endocrinology
ISSN: 2572-5432
Page 49
June 07-08, 2018
London, UK
4
th
World Congress on
Polycystic Ovarian
Syndrome
Background:
Polycystic ovarian syndrome (PCOS) is one of
the most common endocrine conditions affecting women of
reproductive age group with prevalence of approximately 7–10%
worldwide.
Objective:
The objectives of the study were to find out the effect
of standardized fenugreek seed extract as furostanolic saponins
(Furocyst) on reduction in ovarian volume and the number of
ovarian cysts.
Method:
An open-label, multicentric, single-arm, and non-
comparative study was planned on 50 female patients suffering
from PCOS. Patients were enrolled as per inclusion, i.e.
premenopausal women between 18-45 years of age, BMI less
than 42, diagnosed with PCOS, with adequate hepatic, renal
and haematological functions, as well as patients willing to
give informed consent in writing. Patients with hysterectomy/
congenital adrenal hyperplasia/ Cushing’s syndrome/androgen
secreting tumour/ thyroid-dysfunction/ hypo-gonadism were
excluded. Women were allocated to receive Furocyst and were
assessed on parameters of ultrasonographic (USG) and hormonal
diagnosis on the second day of cycle before and every four weeks
within treatment period of 12 weeks
Result:
After treatment for three months with Furocyst, there was
significant reduction in ovary volume (p=0.000), 46% of study
population showed reduction in cyst sizewhohadbigger cyst, 36%
study population showed complete dissolution of cyst who had
small cysts, 12% study population got pregnant and 71% patients
reported regular menstrual cycle on completion of treatment and
LH:FSH ratio was also reduced to normal. Overall 94% of patients
reported positively or got benefitted from standardized fenugreek
seed extract dosing. No changes were observed in liver function
test (LFT), kidney function test (KFT) and haemogram level.
Conclusions:
The present study indicates that standardized
fenugreek seed extract as furostanolic saponins (Furocyst) is
very effective and safe in the management of poly cystic ovary
syndrome in women of reproductive age group.
amritasj@rediffmail.comClinical evaluation of standardized fenugreek seed extract as
furostanolic saponins (Furocyst) in polycystic ovary syndrome
patients
Amrita Sarkari Jaipuriar
1
, Sushil Kumar Gupta
2
, Pawan K Goel
3
and
Gopesh
Lamgora
3
1
Garg Hospital–Uttar Pradesh, India
2
Hormone and Maternity Clinic–Uttar Pradesh, India
3
Chemical Resources (CHERESO), India
J Clin Mol Endocrinol 2018, Volume 3
DOI: 10.21767/2572-5432-C1-003