9 / 15
Page 39
Volume 5
Journal of Pediatric Care
ISSN: 2471-805X
JOINT EVENT
Neonatology 2019
Pediatrics Surgery 2019
April 23-24, 2019
April 23-24, 2019 London, UK
&
23
rd
Edition of International Conference on
Neonatology and Perinatology
4
th
International Conference on
Pediatrics and Pediatric Surgery
Comparative effects of bisphenol s and bisphenol a on the development of female reproductive system in
rats; a neonatal exposure study
Sarwat Jahan
Quaid-i-Azam University, Pakistan
B
isphenol A (BPA) has been well documented for its endocrine disrupting potential however, very little is known
about endocrine disrupting abilities of bisphenol S (BPS). The present study aimed to compare the endocrine
disrupting potentials of BPS with BPA, using female rats as an experimental animal model. On postnatal day 1 (PND
1) female pups born were randomly assigned to seven different treatments. Control group received subcutaneous
injection of castor oil (50 μL) from PND 1 to PND 10. Three groups of female pups were injected subcutaneously
with different concentrations (0.5, 5 and 50 mg/kg in 50 μL castor oil) of BPS, while remaining three groups were
treated with 0.5, 5 and 50 mg/kg BPA. Highest doses treatments of both compounds resulted in delayed puberty
onset and altered estrous cyclicity. Final body weight was significantly high in the highest dose treated groups of
both BPS and BPA. Gonad somatic index, absolute and relative weight of uteri was significantly reduced in BPS (5
and 50 mg/kg) and BPA (5 and 50 mg/kg) treated groups than control. Plasma concentrations of testosterone and
estradiol were significantly increased, while plasma progesterone, luteinizing hormone (LH) and follicle stimulating
hormone (FSH) concentrations were significantly reduced in highest doses treated groups. Dose dependent increase
in the number of cystic follicles in the ovaries was evident along with an increase in the number of atratic follicles.
The results suggest that neonatal exposure to higher concentrations of BPS can lead to BPA like structural and
endocrine alterations in female rats.
sjahan@qau.edu.pkand
drsarwatjahan@gmail.comJ Pediatr Care 2019, Volume 5
DOI: 10.21767/2471-805X-C1-021