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Volume 4, Issue 2 American Journal of Ethnomedicine
ISSN 2348-9502
Natural Products Congress & World Pharma Congress 2017
October 16-18, 2017
3rd World Congress on
NATURAL PRODUCTS CHEMISTRY AND RESEARCH
&
12th WORLD PHARMA CONGRESS
October 16-18, 2017 Budapest, Hungary
Multifunction of saffron and its component
Yukihiro Shoyama
Nagasaki International University, Japan
We confirmed that crocin prevented N-SMase activation, ceramide production and JNK phosphorylation. Exploration of the
crocin’s preventive mechanism in oxidative stress-induced cell death revealed that the activities of GSH reductase. These
results strongly support the importance of the proposed GSH-dependent inhibitory mechanism in oxidative stress-mediated cell
death. The effects of saffron extract and crocin on improving ethanol-induced impairment of learning behaviors of mice in passive
avoidance tasks has been reported. Based on these results, it became evident that saffron extract and crocin prevent the inhibitory
effect of ethanol on Long-Term Potentiation (LTP) in the denatate gyrus in vivo . We examined the sleep-promoting activity of
crocin by monitoring the locomotor activity and electroencephalogram after administration of crocin to mice. Crocin (30 and 100
mg/kg) increased the total time of non-REM sleep by 60 and 170%, respectively, during a 4-h period from 20:00 to 24:00 after its
intraperitoneal administration at a lights-off time on 20:00. Furthermore, the anti-cancer activities against colon cancer cell lines, skin
and colon cancers in mice are also discussed.
Biography
Yukihiro Shoyama worked in MGH in Boston as a Post-doc in 1975. During 1978 to 1991, he worked as an Associate Professor and as a Full Professor during
1991 to 2007 in Kyushu University. During these periods he was the Director of Pharmacognosy Department, the Director of Herbal Garden, and held Deanship
(2004-2006). He moved to Faculty of Pharmaceutical Sciences, Nagasaki International University as a Full Professor from 2007. He was the President of Japanese
Society of Pharmacognosy (2007-2008) and Vice Chairperson of Specialty Committee of Traditional Chinese Medicine, Pharmaceutical Chemistry of World
Federation of Chinese Medicine Societies (2012-2020). His research interests are marijuana studies like structure elucidation of biosynthetic enzyme protein by
x-ray analysis, monoclonal antibodies against over 40 natural bioactive products, biotechnology of medicinal plants and bioactive natural products like saffron
resulting in approximately 400 original papers and over 200 review articles.
Yukihiro Shoyama, American Journal of Ethnomedicine, 4:2
DOI: 10.21767/2348-9502-C1-002