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Volume 4, Issue 2
American Journal of Ethnomedicine
ISSN 2348-9502
Natural Products Congress & World Pharma Congress 2017
October 16-18, 2017
3
rd
World Congress on
NATURAL PRODUCTS CHEMISTRY AND RESEARCH
&
12
th
WORLD PHARMA CONGRESS
October 16-18, 2017 Budapest, Hungary
New cytotoxic diels-alder type adducts from root cultures of
Morus alba
var.
shalun
Rizki Fitriani
Bandung Institute of Technology, Indonesia
M
orus
is one genus of plants belonging to
Moraceae
family that has important economic and medicinal value. The leaves
of some
Morus
plants are indispensable food for silkworm, while their root bark has been used for treatment of diabetes,
arthritis, and rheumatism. Previous phytochemical investigation showed that this genus produces a variety of phenolic compounds
including stilbenes, 2-arylbenzofurans, flavonoids, and Diels-Alder adducts. Diels-Alder type adducts are the unique ones due to
their complex and fascinating structures. Some of these compounds showed important and various bioactivities, such as cytotoxicity,
antioxidant, antimicrobial, anti-inflammatory, and antiviral. The source of biologically important secondary metabolites was
obtained conventionally from the intact plants. However, recent development in plant biotechnological approach has shown the
possibility of plant tissue cultures as an alternative source for producing bioactive secondary metabolites. Therefore, the isolation and
characterization of secondary metabolites from
Morus alba
var.
shalun
root cultures were implemented in this research. Three new
Diels-Alder type adducts (1-3) together with two known Diels-Alder type adducts (4-5) were isolated from the EtOAc extract of liquid
medium and MeOH extract of
Morus alba
var.
shalun
root cultures. The structures of the isolated compounds were elucidated based
on a comprehensive analysis of spectroscopic data, including 1D, 2D, and MS data. Compound 1-5 exhibited significant cytotoxicity
against murine leukemia P-388 cells with IC
50
values 0.7, 0.7, 2.0, 1.7, and 0.6 μg/mL respectively. These results demonstrate the
potency of compound 1-5 as the lead compounds for anticancer agent.
Biography
Rizki Fitriani has completed her Master’s degree in Natural Products Chemistry from Bandung Institute of Technology. She is currently a Doctoral Candidate at the
same university. Her research interests focus on natural products isolation and their structural characterization, as well as bioassay on the isolated pure compounds.
rizkifitrianii@gmail.comRizki Fitriani, American Journal of Ethnomedicine, 4:2
DOI: 10.21767/2348-9502-C1-002