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Volume 4

Nano Research & Applications

ISSN: 2471-9838

Page 27


August 16-18, 2018 | Dublin, Ireland




Edition of International Conference on

Nanopharmaceutics and Advanced Drug Delivery



Nano Congress for

Future Advancements

Nano Congress 2018


Nano Drug Delivery 2018

August 16-18, 2018

Robert K Prud’homme et al., Nano Res Appl 2018, Volume 4

DOI: 10.21767/2471-9838-C3-014

Encapsulation of nanoparticles in composite gel microparticles for lung imaging and drug delivery

Robert K Prud’homme, Nathalie M. Pinkerton, Stacey W. Zhang, Richard L. Youngblood, Dayuan Gao,Shike Li, Bryan R. Benson, John Anthony, Howard

A. Stone


II Patrick J. Sinko

Princeton University, USA


he intravenous delivery of composite gel microparticles (cGMPs) offers a platform for localized treatment of lung cancer.

We describe a method for fabrication of cGMPs with average diameters of 35 to 100 µm using shear emulsification and

microfluidic droplet generation. We characterized the particles and describe the performance of these particles

in vivo


Biodistribution of the cGMPs was selective to the lung after intravenous injection and particle clearance from the lung occurred

in 7 weeks. One-week biodistribution studies demonstrated that larger, uniform particles produced by microfluidics provided

optimal targeting to lung tissue. We demonstrated that highly loaded cGMPs containing a long wavelength fluorophore allow

in vivo

analysis of particle biodistribution without the need for


organ analysis. The release of camptothecin conjugates

from the nanopartricles, and thus, gel microparticles, is tuned fromminutes to days by altering the polarity of the nanoparticle



Robert k Prud’homme is a professor in the Department of Chemical and Biological Engineering at Princeton University. He is the founding director of the Program

in Engineering Biology. His research program focusses on polymer self-assembly applied to drug delivery. The development of Flash NanoPrecipitation (FNP) in

his laboratory enabled the encapsulation of poorly soluble drug compounds and oligonucleotides for therapy directed towards cancer, TB, and injections. FNP is a

scalable and continuous process that is enables integrated processing and spray drying for low cost oral and aerosol formulations. Under sponsorship by the Bill

and Melinda Gates Foundation, the process is being adopted to formulate new compounds coming from TBA, MMV, and DNDi.

[email protected]