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Volume 4 Nano Research & Applications
ISSN: 2471-9838
Page 27
JOINT EVENT
August 16-18, 2018 | Dublin, Ireland
&
12th Edition of International Conference on
Nanopharmaceutics and Advanced Drug Delivery
25th Nano Congress for Future Advancements
Nano Congress 2018
&
Nano Drug Delivery 2018
August 16-18, 2018
Robert K Prud’homme et al., Nano Res Appl 2018, Volume 4
DOI: 10.21767/2471-9838-C3-014
Encapsulation of nanoparticles in composite gel microparticles for lung imaging and drug delivery
Robert K Prud’homme, Nathalie M. Pinkerton, Stacey W. Zhang, Richard L. Youngblood, Dayuan Gao,Shike Li, Bryan R. Benson, John Anthony, Howard
A. Stone and II Patrick J. Sinko
Princeton University, USA
The intravenous delivery of composite gel microparticles (cGMPs) offers a platform for localized treatment of lung cancer.
We describe a method for fabrication of cGMPs with average diameters of 35 to 100 µm using shear emulsification and
microfluidic droplet generation. We characterized the particles and describe the performance of these particles in vivo.
Biodistribution of the cGMPs was selective to the lung after intravenous injection and particle clearance from the lung occurred
in 7 weeks. One-week biodistribution studies demonstrated that larger, uniform particles produced by microfluidics provided
optimal targeting to lung tissue. We demonstrated that highly loaded cGMPs containing a long wavelength fluorophore allow
in vivo analysis of particle biodistribution without the need for ex-vivo organ analysis. The release of camptothecin conjugates
from the nanopartricles, and thus, gel microparticles, is tuned fromminutes to days by altering the polarity of the nanoparticle
core.
Biography
Robert k Prud’homme is a professor in the Department of Chemical and Biological Engineering at Princeton University. He is the founding director of the Program
in Engineering Biology. His research program focusses on polymer self-assembly applied to drug delivery. The development of Flash NanoPrecipitation (FNP) in
his laboratory enabled the encapsulation of poorly soluble drug compounds and oligonucleotides for therapy directed towards cancer, TB, and injections. FNP is a
scalable and continuous process that is enables integrated processing and spray drying for low cost oral and aerosol formulations. Under sponsorship by the Bill
and Melinda Gates Foundation, the process is being adopted to formulate new compounds coming from TBA, MMV, and DNDi.