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Infectious Diseases
and STD-AIDS
Infectious Diseases and STD-AIDS 2018
Journal of Transmitted Diseases and Immunity
ISSN 2471-8084
A p r i l 2 6 , 2 7 2 0 1 8
R o m e , I t a l y
Page 68
J Transm Dis Immun 2018 Volume 2
DOI: 10.21767/2573-0320-C1-003
Background:
Continuous HIV RNA replication, elaboration of pro-inflammatory cytokines and progressive CD4+cell destruction
are hallmarks of HIV infection progression to HIV disease. This research studied the effect of micronutrient supplementation on
plasma HIV RNA load (pVL), interleukin 6 (IL-6), C-reactive protein (CRP) and CD4+ cell counts (CD4+cc) among ART- naive HIV
infected patients.
Materials & Methods:
90 ART-naïve adults (aged 18-59 years) attending two HIV clinics in Kaduna State were recruited after
informed consent. Inclusion criteria were: WHO clinical stage I and II, CD4+ ≥520 cells/µl, and absence of immunosuppressive
and/or psychiatric illness. Patients who became eligible for ART (CD4+ cc ≤500 cells/µL or presence of AIDS-defining illness), or
became pregnant or defaulted from one scheduled clinic visit in the course of the study were excluded. After history and physical
examinations, venous blood was collected for baseline pVL, and serum IL-6 and CRP concentrations, after which each patient
was given one capsule of SYNOVIT TM (micronutrient supplements) and 900 mg of co-trimoxazole to take daily for 48 weeks.
Patients’ CD4+ cc were evaluated quarterly, while pVL, IL-6 and CRP were evaluated at 24 and 48 weeks respectively.
Results:
The pVL, IL-6, CRP and CD4+ cc decreased significantly from baseline to 48 weeks of micronutrient supplementation.
The pVL decreased from 27,105.0 copies/mL to 585.0 copies/mL (p=0.00); serum IL-6 decreased from 1.9 pg/mL to 0.5 pg/mL
(p=0.02); serum CRP reduced from 29.4 ng/mL to 25.8 ng/mL (p=0.03); while CD4+ cc also reduced from 704.5cells/µL to 595.0
cells/µL (p=0.00) respectively.
Conclusion:
48 weeks of micronutrient supplementation reduced pVL, IL-6 and CRP without increasing CD4+ cc in HIV-infected
ART-naïve patients in Kaduna State, Nigeria.
orobiako87@gmail.comMicronutrient supplementation decreased plasma
HIV RNA load and interleukin-6 without increas-
ing CD4+ cell count in HIV-infected antiretroviral
(ART-) naïve patients
Obiako O. R.
1
, Musa B. O. P
1
, Maiha B. B
1
, I Abdu-Aguye
1
, Okonk-
wo L
1
, Balogun Y.
2
, Hassan A.
1
, Babadoko A.
1
, Muktar H. M.
1
and
Mohammed A. A
2
1
Ahmadu Bello University, Zaria
2
University Teaching Hospital, Zaria