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Immunology 2018
J u l y 0 5 - 0 7 , 2 0 1 8
V i e n n a , A u s t r i a
Page 66
Journal of Clinical Immunology and Allergy
ISSN 2471-304X
1 5
t h
I n t e r n a t i o n a l C o n f e r e n c e o n
Immunology
V
irus infections may account for the development of several
cancers, such as HPV16/18 are known to cause around 70%
of cervical cancer cases. Until now, several immunotherapeutic
approaches for virus-induced cancer are under development. Peptide-
based vaccines have several advantages over conventional whole-
protein vaccines in terms of purity, lot-to-lot consistency, production
costs, and the high antigenic specificity. However, the use of peptide
antigens in vaccine development has been hampered by problems,
such as weak immunogenicity coupled with a paucity of potent
adjuvants. Specific T cell immune response is crucial for anti-tumor
immunity. Manipulating specific T cell immunity by Chinese herbal
medicine (CHM) is a promising field to explore. Therefore, we aimed
to investigate whether CHM can modulate specific T cell responses
to apply for the development of cancer vaccine. We have identified a
CHM extract that could increase expression of maturation cytokines
and activation markers of murine bone marrow-derived dendritic cells
(BM-DCs). Furthermore, in a murine TC-1 tumor-bearing model, we
found that the CHM extract could act as an adjuvant to induce cellular
immune responses and anti-tumor effect in peptide vaccine strategy.
We suggested that immune-stimulator CHM combined with cancer
vaccine endows them with increased immunologic activity, which may
be used to bypass the requirement for the conditional adjuvant. Further
delineation of the mechanism may provide new clues for vaccination
strategy.
The efficacy and mechanism of Chinese herbal medicine on the
induction of specific anti-tumor response
Ying-Chyi Song and Hung-Rong Yen
China Medical University, Taichung, Taiwan, China Medical University Hospital, Taichung, Taiwan
Biography
Ying-ChyiSonghascompletedherPhDfromNationalYangMingUniversity
and Postdoctoral studies fromNational Health Research Institutes (NHRI)
in Taiwan. She is an Assistant Professor in China Medical University,
Taiwan. His current research interests are development of cancer vaccines
and immune adjuvants. She has publishedmore than 15 papers in reputed
journals.
songyingchyi@gmail.comYing-Chyi Song et al., Insights Allergy Asthma Bronchitis 2018, Volume: 4
DOI: 10.21767/2471-304X-C1-003