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Volume 2, Issue 3 Ped Health Res 2017 General Pediatrics 2017
September 25-27, 2017
September 25-27, 2017 Chicago, USA
14th World Congress on
General Pediatrics & Adolescent medicine
High IgG1 malaria antibodies level in children is a possible risk factor of black water fever: Case-control
study
Joseph M Bodi, Célestin N Nsibu, Roland L Longenge, Michel N Aloni, Pierre Z Akilimali, Pierre M Tshibassu, Patrick K Kayembe, Ahmeddin H Omar, Kenji
Hirayama, Jan Verhaegen, Aimé Lumaka and Prosper T Lukusa
Kinshasa University, Democratic Republic of Congo
Background: Pathogenesis of acute massive intravascular hemolysis in blackwater fever is very complex. Mostly, malaria immunity
deficiency in expatriates, Quinine and Plasmodium are incriminated. The role of malaria IgG1 antibodies in BWF in older children
supposed to have malaria protective immunity is not well elucidated. This study aimed to determine the profile of malaria IgG1 for
malaria crude antigen in children developing blackwater fever compared to patients with uncomplicated malaria
Methodology: This is a case-control study conducted in 4 medical institutions across Kinshasa. Cases were patients with blackwater
fever (BWF) whereas controls had uncomplicated Plasmodium falciparum malaria (UM). For each case, 2 controls were recruited
and were matched for age, sex and the area of residence. Malaria IgG1 were assessed by standard ELISA and absorbance measured in
an automated plate reader.
Results: The level of antibodies in BWF children were very high compared to uncomplicated malaria [1.95mg/l (IC95%:1.55–2.44)
versus [1.19 mg/l (IC95%: 0.98–1.43)] and p=0,002. The majority of BWF cases (81,4%) were above 5 years old while only 18,6% were
under 5 years old: OR: 1.33 (0.53–3.32). Quinine was used by 95.3% of the BWF cases [OR: 50.19 (10.75–234.42)] p<0.001) versus
uncomplicated malaria. There was no linear correlation between age of patients and the logarithm of antibodies. R2 is totally null
(p=0.335).
Conclusion: Malaria IgG1 antibodies is high in children with BWF, and should be involved in the pathogenesis of the disease,
probably by activating complement system via classical pathway and leading to acute massive hemolysis. No correlation was observed
between increasing of antibodies and age of patients.
Biography
Joseph M Bodi is a researcher at the Kinshasa University in Democratic Republic of Congo.
Joseph M Bodi et al., Ped Health Res 2017, 2:3
DOI: 10.21767/2574-2817-C1-002