general-pediatrics-2017-scientifictracks-abstracts

3 / 16

Page 28
Notes:
conferenceseries .com
Volume 2, Issue 3 Ped Health Res 2017 General Pediatrics 2017
September 25-27, 2017
September 25-27, 2017 Chicago, USA
14th World Congress on
General Pediatrics & Adolescent medicine
Serum leptin level as a marker of bone metabolism in pre-term babies
Petra Kaniokova Vesela1, 2 and Radek Kaniok1, 2
1Hospital in Karviná, Czech Republic
2Charles University, Czech Republic
Many hormonal changes can be observed in hormonal enviroment after birth. These changes lead to an increase in endosteal bone
resorption.The adapation process in preterm infants is different, and depends on thematurity.Thus, twomainstreamhypotheses
for the role of leptin on bone have emerged: (i) direct regulation through increased osteoblast proliferation and differentiation and
(ii) indirect suppression of bone formation through a hypothalamic relay. At the present time, it remains unclear whether these
effects are relevant in only extreme circumstances (i.e. models with complete deficiency) or play an important homeostatic role in
the regulation of peak bone acquisition and skeletal remodeling. The leptin acts primarily through peripheral pathways and increases
osteoblast numbers and activity. Leptin plays an important role in the regulation of bone metabolism. It directly influences osteoblast
proliferation and differentiation. Indirectly, leptin affects bone formation through a hypothalamic relay. The leptin level in the cord
blood of preterm newborns is significantly lower than the leptin level in the cord blood of term delivered newborns. However, leptin
levels in the cord blood in newborns delivered between 32+0 and 36+6 weeks of gestation do not significantly influence the lumbar
spine BMD at 2 years of age.
Biography
Petra Kaniokova Vesela has completed her medical studies from Charles University and is working at Pediatric Department. She is a PhD student at Charles University.
She has published 4 papers in reputed journals.
Petra Kaniokova Vesela et al., Ped Health Res 2017, 2:3
DOI: 10.21767/2574-2817-C1-002