euro-gastro-2018-scientifictracks

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A n n u a l E u r o p e a n C o n f e r e n c e o n

Gastroenterology

Euro Gastro 2018

J u n e 1 9 - 2 0 , 2 0 1 8

P a r i s , F r a n c e

Page 44

Journal of Clinical Gastroenterology and Hepatology

ISSN 2575-7733

rugs are an important cause of liver injury. More than 900 drugs, toxins,

and herbs have been reported to cause liver injury, and drugs account for

20-40% of all instances of fulminant hepatic failure. Physicians must be aware

in identifying drug-related liver injury because early detection can decrease

the severity of hepatotoxicity if the drug is discontinued. The manifestations

of drug-induced hepatotoxicity are highly variable, ranging from asymptomatic

elevation of liver enzymes to fulminant hepatic failure. The liver metabolizes

virtually every drug or toxin introduced in the body. Most drugs are lipophilic

(fat soluble), enabling easy absorption across cell membranes. In the body,

they are rendered hydrophilic (water soluble) by biochemical processes in the

hepatocyte to enable inactivation and easy excretion. Metabolism of drugs

occurs in 2 phases. In the phase 1 reaction, the drug is made polar by oxidation

or hydroxylation. All drugs may not undergo this step, and some may directly

undergo the phase 2 reaction. The cytochrome P-450 enzymes catalyze phase

1 reactions. Most of these intermediate products are transient and highly

reactive. These reactions may result in the formation of metabolites that are

far more toxic than the parent substrate and may result in liver injury. As an

example, the metabolite of acetaminophen is N -acetyl-p-benzoquinone-imine

(NAPQI) and is produced with ingestion of high doses. We will present case

series of patients presented by hepatotoxicity to The Poison Control Centre at

Ain Shams University Hospitals during the las three years.

Biography

Mona E Moussa has completed her MD and Postdoctoral

studies from Ain Shams University. She is the Chairman of the

Toxicology and Forensic department at Ain Shams University,

one of the eminent universities in Egypt. She is the Director of

Egyptian fellowship program of Clinical Toxicology and Head

of Clinical Toxicology at Helwan University. She has published

more than 80 papers in reputed journals and has been serving

as an Editorial Board Member of repute.

Mona E Moussa

Ain Shams University, Egypt

Mona E Moussa, J Clin Gastroenterol Hepatol 2018, Volume: 2

DOI: 10.21767/2575-7733-C1-002

Hepatic biotransformation of drugs and drug-induced liver

disorders