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Biochemistry & Molecular Biology Journal
ISSN: 2471-8084
Page 22
Biotechnology, Biomarkers & Systems Biology
March 04-05, 2019 | Amsterdam, Netherlands
International Conference on
Biotechnology, Biomarkers & Systems Biology 2019
A
retrospective analysis of the 35-year absence of maternal mortality in critical obstetrics, in
different countries, was due to the timely decentralization of macro-circulation, detoxification
and analgesia. Macro-circulation was decentralized once the systemic perfusion pressure has
been established; which is the difference between the mean blood pressure and the pressure of
the capillary resistance, and what contribute to by decreasing the tissue hypoxia marker pCO
2
(pCO
2
AV gap >6 mm Hg) due to micro-circulatory-mitochondrial recruitment, through improved
microcirculation at the level of the capillary-cell metabolic area: metabolic capillary ↔ cells ↔
mitochondria; with ameliorate of the venous return compliance and reduction (pCO
2
AV gap <6mm
Hg),andrespectively,diminishesofthe microcirculatory-mitochondrialdistresssyndrome(MMDs),
and stopping expansion syndrome of acute multi-organ dysfunction. In cases of development of
respiratory-pulmonary pCO
2
↑ (ARDs), confirmed ↓ PaO
2
/FiO
2
↓300 to Acute Respiratory Distress
Syndrome (Berlin definition, 2012), thus also aggravates the MMDs (pCO
2
AV gap >6 mmHg),
mitochondrial collapse and the recruitment of the microcirculatory-mitochondrial is supplemented
with multi-organ support therapy (MOST), including detoxification: alveolar recruitment
through respiratory support in specific ventilation modes, predominantly APRV, with permissive
hypercapnia at a normal pH; MOST-extracorporeal with technical support. Extracorporeal life
support organization-ELSO; modelling of extra-vascular pulmonary fluid index EVLWI; Th4-Th5
thoracic epidural block; active detoxification methods. The absence of decreasing of the pCO
2
tissue hypoxia marker at the pCO
2
AV gap ↓ 5.0 mm Hg after microcirculatory- mitochondrial
recruitment, rejects the necrosis/apoptosis, hypo- (an) ergic cell and proves the mitochondrial
eu-energetic metabolic remodelling with the elimination of the hypo-(an) ergic mitochondria
performed by liposomal clearance (mitophagy), thus demonstrating eu-ergic mitochondria with
the normalization of mitochondrial uniporter-Ca++ and mitochondrial permeability pore transition,
which productively inactivate the toxic forms of oxygen and nitrogen.
Biography
Ilie Vasiliev, MD, is an Academy Professor of
Medicine. The First Senior Vice-President the World
Academy of Medical Sciences The Chairman of the
General Council of the World Academy of Medical
Sciences (World Council). The Chairman of the
“WAMS Moldovan National Committee” Senior
Executive Board Member of the World Academy
of Medical Sciences Senior Fellow of the Academy
of the World Academy of Medical Sciences Full
Membership of the “Academy Faculty” Executive
Board Membership of the WAMS' International
Medical Research Council (IMREC).
ilievasiliev@gmail.comVasiliev I et al., Biochem Mol biol J 2019, Volume:5
DOI: 10.21767/2471-8084-C1-022
The recruitment of microcirculatory-mitochondrial of criti-
cal obstetric situations in the complex multi-organ support
therapy reduces pCO
2
(AV gap) and the development of the
syndrome of acute multi-organ dysfunction
Vasiliev I
1,9
, Vasilieva Maria
1,5
, Vasilieva Irina
1,5
, Ghicavîi V
2
,
Litarczek G
3
, Friptu V
4,5
, Gladun S
4,5
, Diug V
4,5
, Vartanov V
1,6
,
Stavrou I
7
, Tarabrin O
8
and D Ambra Mirta
1,10
1
World Academy of Medical Sciences, Netherlands
2
Academy of Sciences of the Republic of Moldova, State University
of Medicine and Pharmacy N Testemitanu, Republic of Moldova
3
Fundeni Institute Bucharest, Romania
4
Mother and Child Research Institute, Republic of Moldova
5
State University of Medicine and Pharmacy Nicolae Testimitanu, Republic of Moldova
6
State Medical University of Samara, The Russian Federation
7
University Hospital Aretaieion, Athens Medical School-National and
Kapodistrian University of Athens, Greece
8
Odesa National Medicine University, Ukraine
9
Private Hospital Medical Institution LTD “Via-Intosana” Republic of Moldova
10
Medicine University of Buenos Aires-WAMS, Argentina