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Volume 3, Issue 4 (Suppl)
Polym Sci
ISSN: 2471-9935 Polym Sci, an open access journal
October 12-13, 2017 Osaka, Japan
Annual Meeting on
Biopolymers and Drug Delivery Systems
Biopolymers Meeting 2017
October 12-13 2017
Page 66
Polym Sci 2017, 3:4
DOI: 10.4172/2471-9935-C1-006
Design, formulation and evaluation of transdermal patch of Propranolol using chamomile essential oil as
permeation enhancer:
In vitro in vivo
chapter
Muhammad Akhlaq
1
, Muhammad Imran
1
and Muhammad Zeeshan Danish
2
1
Gomal University, Pakistan
2
University of Punjab, Pakistan
Statement of the Problem:
Skin permeation enhancement technology is a rapidly emerging field which would expressively increase
the number of drugs which is suitable for transdermal drug delivery. Transdermal drug administration route offers many benefits over
oral administration of drugs and has stimulated research to find ways to overcome the barrier function of the skin by use of various
enhancers’ approaches. The exploration for the ideal skin penetration enhancer has been the emphasis of significant research effort
over a number of eras. Many potent enhancers have been revealed, but in most of the cases, their effects are associated with toxicity.
Methodology:
Physiochemical evaluations like majorly, drug content and aging, moisture uptake and thickness were performed
to rationalize the suitability and pertinence of the formulation.
In vitro
and
ex vivo
and
in vivo
studies were carried out using Franz
diffusion cell using albino rabbits (pharmacokinetics). In vitro permeation studies demonstrated a significant enhancement with
chamomile essential oil.
Findings:
Formulation with 10% chamomile essential oil exhibited the best permeation of the model drug evidenced by kinetic
parameters. The pharmacokinetic parameters, such as the C
max,
T
max,
MRT, AUCo-t and T1/2 derived from transdermal administration
differed significantly (p<0.05) from those estimated fromoral administration. The C
max
of model drug after transdermal administration
of optimized patch formulation was found to be 88.37±2.3 µg/ml and the plasma concentration was maintained for 36 hours which
was in good agreement with the reported plasma levels of model drug reported in published clinical studies. In variance to oral
delivery well sustained activity was observed over a period of 24 hours after transdermal administration.
Conclusion & Significance:
Taking together, the transdermal patch using indigenous natural chamomile essential oil can be
successively used to achieve better patient compliance in contrast to the oral conventional tablets in pharmaceutical industries.
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