Dr. Shuo Li

Dr. Shuo Li
Cleveland Clinic, Cleveland, OH, USA
 
Research Interest
MS is an autoimmune disorder of the central nervous system that involves inflammatory demyelination and chronic neurodegeneration. In my PhD thesis projects, my research has focused on investigating the pathogenesis of neuroglial disability in Multiple Sclerosis (MS) and seek to identify neuroprotective therapies. We elucidated that neuronal mitochondrial dysfunction regulates oligodendrocyte demyelination by decreased N-acetyl aspartate in MS. We further determined the role of changes in methionine metabolism and histone methylation in mitochondrial defects in MS. Interestingly, neuronal hemoglobin interacts with mitochondria and with nuclear proteins, and plays a beneficial role in neuronal energetics. The type II transmembrane serine protease (TTSP) of the trypsin subfamily are versatile and functionally important. In my postdoctoral projects, my research interest has extended to include TTSP essential for metabolic homeostasis and cardiac function. In particular, I am studying a hepatic serine protease, hepsin, and a cardiac serine protease, corin. Our most recent data indicated that hepsin regulates liver glucose and lipid metabolism in mice, and may play a role as a therapeutic target for treatment of obesity and diabetes. In addition, I am studying the regulatory mechanism for intracellular processing and extracellular expression of corin.
 

Relevant Conferences