neurology-2018-posters-abstracts

t h

E u r o S c i C o n C o n f e r e n c e o n

Neurology & Neurological

Disorders

Neurology 2018

J u l y 1 2 - 1 3 , 2 0 1 8

P a r i s , F r a n c e

Page 107

Journal of Neurology and Neuroscience

ISSN: 2171-6625

lioblastoma is a lethal cancer with a median survival of about 15 months. It is a well-known fact that most Glioblastoma’s

are rich in collagens. Specifically, the mesenchymal subtype of Glioblastoma, which has the worst prognosis, is enriched

with numerous extracellular matrix proteins such as collagens. While collagen accumulation can be viewed as a downstream

effect of mesenchymal differentiation, it was found that the feed forward increases in collagen, extracellular matrix stiffness

and biomechanical influences cause enhanced selfrenewal and mesenchymal transition in glioma stem cells with a consequent

increase in treatment resistance of these cells. Further, recent studies have also shown that mechanical stress plays an

overarching role in the regulation of TAZ signaling. TAZ is a mediator of mesenchymal differentiation in glioma, which relates

with collagen stiffness, promotes mesenchymal transition and gliomagenesis via TAZ signaling. D-penicillamine is a known

inhibitor of collagen maturation, which acts by increasing the conversion of insoluble to soluble collagen and disrupting the

formation of intermolecular bonds. The therapeutic benefit of D-penicillamine has not been extensively evaluated in Glioblastoma

especially in the context of glioma stem cells, which represent faithful models of this disease. Directing therapeutic agents such

as D-penicillamine towards deeply embedded brain tumours with biophysical barriers such as blood brain barrier and collagen

remains a challenge. Hence, in the present study it is proposed to load D-penicillamine into Nano lipid carriers, which can

accumulate passively in tumours via leaky tumour vasculature, caused by focused ultrasound. These triggered release strategies

disrupt the blood brain barrier, confirming deep penetration in tumours, and overcome the biophysical constraints, which tackle

both the challenges (drug delivery and collagen disruption) simultaneously.

D-PENICILLAMINE LOADED NANO LIPID CARRIERS FOR

TARGETING GLIOBLASTOMA

B. Mahendran

, DV Gowda

, VVS Narayana Reddy

Department of Pharmaceutics, JSS College of Pharmacy, JSS University, Mysuru, India

Department of Pharmaceutics, JSS College of Pharmacy, Ootacamund, India

J Neurol Neurosci 2018, Volume: 9

DOI: 10.21767/2171-6625-C1-009