neuroimmunology-2017-posters-accepted-abstracts

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ISSN:2171-6625

September 18-19, 2017 | Dallas, USA

International Conference on

NEUROLOGY AND NEUROIMMUNOLOGY

or effective control of seizures, antiepileptic drugs (AEDs)

are administered at higher dose which is associated with

several adverse effects. This study envisages antiepileptic

and neuroprotective potential of Tulsi, a commonly used

herb for its immunomodulatory property. The optimal dose

of Ocimum sanctum hydroalcoholic extract (OSHE) was

determined using Maximal Electroshock seizure (MES) and

Pentylenetetrazol (PTZ) induced seizure models in Wistar

rats (200 to 250g) after administering OSHE (200 – 1000 mg/

kg) orally for 14 days. For interaction study, OSHE optimal

dose in combination with maximum and submaximal

therapeutic doses of valproate was administered for 14

days. Serum levels of valproate were estimated using

HPLC for pharmacokinetic study. For pharmacodynamic

interaction, antiepileptic effect on above seizure models,

neurobehavioral effect using Morris water maze, Passive

avoidance and Elevated plus maze tests and antioxidant

capacity were assessed. OSHE 1000 mg/kg was found to be

optimal providing 50 % protection against both MES and

PTZ-induced seizures. Combination of OSHE with valproate

did not alter antiepileptic efficacy of valproate significantly.

However, the combination showed better memory retention

potential in neurobehavioral tests and protection against

oxidative stress compared to valproate alone treated groups.

Pharmacokinetic parameters did not reveal any significant

change in combination group compared to valproate alone.

Ocimum, although having per se antiepileptic action, did

not affect antiepileptic action of valproate in combination.

However, combination treatment has an edge over valproate

alone by better neurobehavioral function and reduced

oxidative stress, predicting adjuvant potential of Ocimum in

epilepsy treatment.

Potential of Ocimum sanctum as an adjuvant with sodium valproate in management of epilepsy: An

experimental study in rats

Sudhir Chandra Sarangi, Dipesh Joshi, Thomas Kaleekal, Ritesh Kumar

and

Yogendra Kumar Gupta

All India Institute of Medical Sciences, India

J Neurol Neurosci, 8:5

DOI: 10.21767/2171-6625-C1-003