Sangeeta Tiwari

Sangeeta Tiwari
Department of Microbiology and Immunology,Albert Einstein College of Medicine, Bronx, New York


My research work presently is focused on developing novel Vaccine candidates and drug targets against Mycobacterium tuberculosis (Mtb), a successful human pathogen. Long chemotherapy and only vaccine BCG, which provides limited protection against pulmonary TB in adult?s, necessities the need to find novel vaccines and drug targets. I have generated complete set of precise null Mtb deletion mutants to study bacterial pathogenesis, vaccine development and novel drug targets. Using in vitro and in vivo models from cell lines to animals I have validated the essentiality and virulence of these novel mutants. My research has identified a novel drug target and I am collaborating with an expert in fragment based drug discovery to find inhibitor drugs. Further my research has identified new attenuated strains with vaccine potential and they have been genetically engineered to express fluorescence markers to track infection during vaccine studies. Due to my international research experience, I am part of an international scientific network with collaborators in USA, UK, India and Brazil. I was awarded JRF and SRF fellowship by Council of Scientific and Industrial Research to pursue my Ph.D. in ?Molecular and Biochemical characterization of potential drug targets of Mtb? with Dr. P.K. Chakraborti at Institute of Microbial Technology /India. My findings sparked my interest in studying; the role of this virulence factor in bacterial evasion of host immune responses and Dr. J.D. MacMicking (HHMI) enthusiastically invited me to join Yale University and work on it. During these studies I discovered a novel mechanism of action of potent host antimicrobial immune response effector, which resulted in ?Nature Immunology? and ?Immunity? as first author publications. Currently I am working with Dr. William R. Jacobs Jr., an eminent Howard Hughes investigator (HHMI) at Albert Einstein College of Medicine in New York. I enjoy scientific editing, writing, scientific critiques, management, leadership, mentoring and teaching experience.

Research Interest

drug targets against Mycobacterium tuberculosis (Mtb)