Manfred Göthert

Manfred Göthert Manfred Göthert
President of French Pharmacologists and President of EPHAR AND IUPHAR [FORMERLY], Germany.


On 12 December 1939, I was Manfred Göthert, the son of the physicist (focal point Aerodynamics) Dr. rer. nat. RUDOLF Göthert and his wife Louise, born FREISE, born in Braunschweig. Due to the Second World War and the post-war period was marked my childhood until the age of 10 by Autobiographies 208 frequent moves with school change. In the first years after the enrollment 1¼ in 1946, I switched between two village schools - one in Mesmerode in Hannover, the other in Zech in Lindau at Lake Constance - twice back and forth, with each period in the two villages was between two and five months. Hereupon we moved for two years to France in the near the airport Marseille where my father had taken a job in the aircraft development (in Germany Research aircraft was banned after the war) and I primary school attended by Rognac in Marseille. We were treated kindly by the French, which two and a half years after the withdrawal of German occupation troops has not been granted. Half a year after returning to Germany and six months Elementary School in Hildesheim I concluded primary education, despite the many retraining, usually after the 4th class. In the Unlike this troubled primary school I spent nine years Secondary School until graduation on the MARTINO-Katharineum in Braunschweig. The medical school I graduated at five universities - Hamburg Freiburg, Innsbruck, Vienna and Goettingen. I was particularly impressed by two professors in Freiburg in the subjects of Physiology and Biochemistry, ALBRECHT FLECKENSTEIN and Helmut Holzer, which already at that time I was considering, after graduation for a limited time to work in one of the two subjects. In 1966 married I mean many years of study girlfriend Dr. med. IRMGARD KARIN SCHEIBLER. Our family has been completely through the birth of our three sons. My work as a pharmacologist, I started at the Department of Pharmacology University of Hamburg. I did not realize that this institute within the faculty and outside in the art had no reputation. My first research was dedicated to the poisonous gas carbon monoxide (CO), which I succeeded in relatively a short time as a co-author of five publications (four in charge) to publish. Within clinical therapeutically important drugs I examined First, the side effects of anesthetics and their causes, particularly the causal significance of sympathoadrenal system. I habilitated me at the age of 31 years with a work from this area. These studies were the starting point for developing a biochemical model, in which the targets of general anesthetics and ethanol are determined could. Specifically, it was two ligand-gated ion channels, the nicotinic acetylcholine receptor channel and the 5-HT3-receptor channel. In 1978, I was on the C3 professor of Biochemical Neuropharmacology appointed to food than succeed Klaus Starke. The central theme of Institute under the direction of Hans-Joachim SCHÜMANN was the analysis of Neurotransmitter systems in the peripheral and central nervous system. In The Centre my own research program focused on the identification of presynaptic 5-HT autoreceptors and presynaptic heteroreceptors on the Axon terminals of the 5-HT neurons in the cerebrum. I also worked on open Questions for the modulation of transmitter release from noradrenaline and dopamine Neurons. The last stop of my official career was the C4 professor of pharmacology and Toxicology at the Institute of Pharmacology and Toxicology of the University Manfred Göthert 209 Bonn, where I worked until my retirement in 2006. Rejection the call on the C4 site at the Medical University of Lübeck I have never looked back. In Bonn I continued my work in several begun in Hamburg and Essen Research projects continued. In addition, I studied in the context the resulting under my involvement Collaborative Research Centre (SFB) 400 biochemical effects of single nucleotide polymorphisms (SNPs) on 5-HT receptors. By changing the function of SNPs, the pathogenesis neuropsychiatric disorders and the pharmacological properties of 5-HT receptors modify. Increasingly I took laborious Activities related to my scientific expertise and academic administration are: Dean of the Medical Faculty (4 ½ years), President of the German Society for Experimental and Clinical Pharmacology and Toxicology (DGPT; 3 years), President of the Federation of European Pharmacological Societies (EPHAR, 2 years), Vice-President of the International Society of serotonin research (4 years), editor of several journals, Participation in the organization of symposia and conferences, among others IUPHAR Congress 1998 EPHAR Congress in Porto in 2004, three satellite symposia of IUPHAR- or EPHAR Congresses 1990 1998 and 2004, elected peer reviewer of Pharmacology at the German Research Foundation (DFG), employees in an institute for the development of a drug-positive list. Diverse honors among other things, Dr. Martini Prize, an elected member of the Polish Academy of Arts and Sciences and the German National Academy of Sciences LEOPOLDINA, Dr. h. C. the medical universities and Bialystok Katowize, Poland, honorary memberships in the Polish Pharmacological.

Research Interest

Pharmacology and Toxicology